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Literature DB >> 6237265

Evidence for an antagonistic action of tabernanthine on hypoxia-induced changes in brain serotonin levels.

E Mocaër-Cretet, M Prioux-Guyonneau, F Redjimi, Y Cohen, C Jacquot.

Abstract

The effects of tabernanthine on serotonin (5-HT) levels were determined in several brain areas of rats exposed to various simulated altitudes (1800, 5200, 7000 m). The 5-HT synthesis inhibitor, para-chlorophenylalanine (PCPA), was used to dissociate the effects occurring at synthesis and release levels. Tabernanthine antagonized the decrease in hypothalamic 5-HT levels induced by a 7000 m hypoxia and also suppressed the decrease in PCPA-induced depletion observed at 5200 and 7000 m in the hypothalamus, the striatum and the rest of the brain. It was assumed that tabernanthine stimulates different steps of 5-HT metabolism. These effects, revealed by hypoxia, are related to other peripheral and central properties of this drug.

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Year: 1984 PMID： 6237265 DOI： 10.1007/bf00501431

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

22 in total

1. [SOME PHARMACOLOGICAL PROPERTIES OF 12 NATURAL AND 11 PARTIALLY SYNTHETICALLY DERIVED INDOLE ALKALOIDS FROM TROPICAL APOCYANACEAE OF THE SUB-TRIBE TABERNAEMONTANINAE].

Authors: G ZETLER
Journal: Arzneimittelforschung Date: 1964-12

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Authors: R M Brown; S R Snider; A Carlsson
Journal: J Neural Transm Date: 1974 Impact factor: 3.575

3. Comparative effects of p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid.

Authors: F P Miller; R H Cox; W R Snodgrass; R P Maickel
Journal: Biochem Pharmacol Date: 1970-02 Impact factor: 5.858

4. gamma-Aminobutyric acid (GABA) receptor stimulation. III. Effect of progabide (SL 76002) on norepinephrine, dopamine and 5-hydroxytryptamine turnover in rat brain areas.

Authors: B Scatton; B Zivkovic; J Dedek; K G Lloyd; J Constantinidis; R Tissot; G Bartholini
Journal: J Pharmacol Exp Ther Date: 1982-03 Impact factor: 4.030

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Authors: J N Davis; L T Giron; E Stanton; W Maury
Journal: Adv Neurol Date: 1979

6. The effect of various stimulated altitudes on the turnover of norepinephrine and dopamine in the central nervous system of rats.

Authors: M Prioux-Guyonneau; E Cretet; C Jacquot; J R Rapin; Y Cohen
Journal: Pflugers Arch Date: 1979-06-12 Impact factor: 3.657

7. A comparison of an improved o-phthalaldehyde fluorometric method and high pressure liquid chromatography in the determination of brain 5-hydroxyindoles of rats treated with L-tryptophan and p-chlorophenyl-alanine.

Authors: G Curzon; B D Kantamaneni; M D Tricklebank
Journal: Br J Pharmacol Date: 1981-06 Impact factor: 8.739

1. Ibogaine modulates cocaine responses which are altered due to environmental habituation: in vivo microvoltammetric and behavioral studies.

Authors: P A Broderick; F T Phelan; F Eng; R T Wechsler
Journal: Pharmacol Biochem Behav Date: 1994-11 Impact factor: 3.533

1 in total