Literature DB >> 7469787

Characteristics of haloethylene-induced acetonemia in rats.

J G Filser, H M Bolt.   

Abstract

A series of halogenated ethylenes (vinyl chloride, vinylidene fluoride, cis- and trans-1,2-dichloroethylene, perchloroethylene) induces increased acetone exhalation in rats. Exposures of differently pre-treated rats to vinylidene fluoride suggest that a metabolite of the haloethylene must be envolved in eliciting this formation of acetone. This conclusion is based on (a)dependence of acetone exhalation on the concentration of vinylidene fluoride, (b)effect of inducing agents, (c)effect of pyrazol, a metabolic inhibitor, (d)effect of cysteine, (e)effect of hypoxia and (f)the time course of acetone exhalation.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7469787     DOI： 10.1007/bf01270908

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  9 in total

1.  Disposition of (1,2-14C) vinyl chloride in the rat.

Authors:  H M Bolt; H Kappus; A Buchter; W Bolt
Journal:  Arch Toxicol       Date:  1976-06-08       Impact factor: 5.153

2.  Effect of 1,1-dichloroethylene exposure on hepatic mitochondria.

Authors:  R J Jaeger
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1977-09

3.  Disposition of tetrachloro(14C)ethylene following oral and inhalation exposure in rats.

Authors:  D G Pegg; J A Zempel; W H Braun; P G Watanabe
Journal:  Toxicol Appl Pharmacol       Date:  1979-12       Impact factor: 4.219

Review 4.  Chemical reactivity, biotransformation, and toxicity of polychlorinated aliphatic compounds.

Authors:  G Bonse; D Henschler
Journal:  CRC Crit Rev Toxicol       Date:  1976-10

5.  Pharmacokinetics of halogenated ethylenes in rats.

Authors:  J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1979-06-08       Impact factor: 5.153

6.  Disulfiram-induced acetonemia in the rat and man.

Authors:  E G DeMaster; H T Nagasawa
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1977-10

7.  The rapid reduction of disulfiram in blood and plasma.

Authors:  J Cobby; M Mayersohn; S Selliah
Journal:  J Pharmacol Exp Ther       Date:  1977-09       Impact factor: 4.030

8.  Binding kinetics of vinyl chloride and vinyl bromide at very low doses.

Authors:  H M Bolt; J G Filser; R J Laib; H Ottenwälder
Journal:  Arch Toxicol Suppl       Date:  1980

9.  1,1-Dichloroethylene hepatotoxicity: proposed mechanism of action and distribution and binding of 14C radioactivity following inhalation exposure in rats.

Authors:  R J Jaeger; L G Shoner; L Coffman
Journal:  Environ Health Perspect       Date:  1977-12       Impact factor: 9.031
  9 in total
  4 in total

1.  Inhalation pharmacokinetics based on gas uptake studies. IV. The endogenous production of volatile compounds.

Authors:  J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1983-02       Impact factor: 5.153

2.  Inhalation pharmacokinetics based on gas uptake studies. II. Pharmacokinetics of acetone in rats.

Authors:  E Hallier; J G Filser; H M Bolt
Journal:  Arch Toxicol       Date:  1981-07       Impact factor: 5.153

3.  Biological activation of 1,3-butadiene to vinyl oxirane by rat liver microsomes and expiration of the reactive metabolite by exposed rats.

Authors:  H M Bolt; G Schmiedel; J G Filser; H P Rolzhäuser; K Lieser; D Wistuba; V Schurig
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

4.  Increased acetone exhalation induced by metabolites of halogenated C1 and C2 compounds.

Authors:  J G Filser; P Jung; H M Bolt
Journal:  Arch Toxicol       Date:  1982-01       Impact factor: 5.153
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.