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Literature DB >> 7464987

Serotonin in experimental histidinemia.

Abstract

An experimental histidinemia was obtained in rats by in vivo administration of nitromethane, a histidase inhibitor. The magnitude of increase in plasma histidine in the nitromethane-treated rats was in the same range as that in the histidinemic subjects. No modifications were observed in the serotonin concentrations in blood or in various areas of brain between the nitromethane-treated rats and the control rats. No dramatic modifications of serotonin metabolism seem to be implicated in histidinemia, unlike phenylketonuria.

Entities: Chemical Disease Gene Species

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Year: 1980 PMID： 7464987 DOI： 10.1007/bf00965789

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

22 in total

Serotonin in experimental histidinemia.

1. The relationship between decreased 5-hydroxyindole metabolism and mental defect in phenylketonuria.

2. Tryptophan metabolism in phenylketonurics.

3. The enzymatic defect in histidinemia.

4. Brain serotonin content: physiological regulation by plasma neutral amino acids.

5. A case of histidinemia controlled with a low histidine diet.

6. Tryptophan hydroxylation in mammalian systems.

7. Fluorometric determination of histidine.

Review 8. Congenital and acquired disturbances of histidine metabolism.

9. Histidinemia produced in the rat by treatment with nitromethane1.

10. Effects of phenylalanine diet on brain serotonin in the rat.

1. Urinary volatile metabolites of amygdala-kindled mice reveal novel biomarkers associated with temporal lobe epilepsy.