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Literature DB >> 5453311

A new antibiotic, negamycin.

M Hamada, T Takeuchi, S Kondo, Y Ikeda, H Naganawa.

Abstract

Entities: Chemical

Mesh：

Substances：
Anti-Bacterial Agents

Year: 1970 PMID： 5453311 DOI： 10.7164/antibiotics.23.170

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

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11 in total

1. Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Authors: Nelson B Olivier; Roger B Altman; Jonas Noeske; Gregory S Basarab; Erin Code; Andrew D Ferguson; Ning Gao; Jian Huang; Manuel F Juette; Stephania Livchak; Matthew D Miller; D Bryan Prince; Jamie H D Cate; Ed T Buurman; Scott C Blanchard
Journal: Proc Natl Acad Sci U S A Date: 2014-11-03 Impact factor: 11.205

Review 2. Chemotherapeutics overcoming nonsense mutation-associated genetic diseases: medicinal chemistry of negamycin.

Authors: Akihiro Taguchi; Keisuke Hamada; Yoshio Hayashi
Journal: J Antibiot (Tokyo) Date: 2017-09-27 Impact factor: 2.649

3. Structure-Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates.

Authors: Keisuke Hamada; Akihiro Taguchi; Masaya Kotake; Suguru Aita; Saori Murakami; Kentaro Takayama; Fumika Yakushiji; Yoshio Hayashi
Journal: ACS Med Chem Lett Date: 2015-05-11 Impact factor: 4.345

4. Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy.

Authors: Akihiro Taguchi; Shigenobu Nishiguchi; Masataka Shiozuka; Takao Nomoto; Mayuko Ina; Shouta Nojima; Ryoichi Matsuda; Yoshiaki Nonomura; Yoshiaki Kiso; Yuri Yamazaki; Fumika Yakushiji; Yoshio Hayashi
Journal: ACS Med Chem Lett Date: 2012-01-02 Impact factor: 4.345

5. Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens.

Authors: David C McKinney; Gregory S Basarab; Alexis I Cocozaki; Melinda A Foulk; Matthew D Miller; Anatoly M Ruvinsky; Clay W Scott; Kumar Thakur; Liang Zhao; Ed T Buurman; Sridhar Narayan
Journal: ACS Med Chem Lett Date: 2015-07-12 Impact factor: 4.345

6. Structure-Activity Relationship Study of Leucyl-3-epi-deoxynegamycin for Potent Premature Termination Codon Readthrough.

Authors: Akihiro Taguchi; Keisuke Hamada; Masataka Shiozuka; Misaki Kobayashi; Saori Murakami; Kentaro Takayama; Atsuhiko Taniguchi; Takeo Usui; Ryoichi Matsuda; Yoshio Hayashi
Journal: ACS Med Chem Lett Date: 2017-09-29 Impact factor: 4.345

A new antibiotic, negamycin.

1. Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Review 2. Chemotherapeutics overcoming nonsense mutation-associated genetic diseases: medicinal chemistry of negamycin.

3. Structure-Activity Relationship Studies of 3-epi-Deoxynegamycin Derivatives as Potent Readthrough Drug Candidates.

4. Negamycin analogue with readthrough-promoting activity as a potential drug candidate for duchenne muscular dystrophy.

5. Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens.

6. Structure-Activity Relationship Study of Leucyl-3-epi-deoxynegamycin for Potent Premature Termination Codon Readthrough.

7. Actual new cancer-causing hydrazines, hydrazides, and hydrazones.

8. Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination.

9. New Negamycin-Based Potent Readthrough Derivative Effective against TGA-Type Nonsense Mutations.

10. Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA.