Literature DB >> 7459230

Somatic-cell hybrids producing antibodies against CEA.

G T Rogers, G A Rawlins, K D Bagshawe.   

Abstract

Monoclonal antibodies to carcinoembryonic antigen (CEA) promise improved specificity for the measurement of this widely expressed human cancer antigen. A mouse monoclonal antibody binds weakly to CEA in perchloric acid extracts of tumour but strongly to CEA similarly isolated from serum, and its spectrum of cancer detection differs from conventional antisera.

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Year:  1981        PMID： 7459230      PMCID： PMC2010494          DOI： 10.1038/bjc.1981.1

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  10 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors:  F C GREENWOOD; W M HUNTER; J S GLOVER
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

Review 3.  Heterogeneity of carcinoembryonic antigen. Implications on its role as a tumour marker substance.

Authors:  G T Rogers
Journal:  Biochim Biophys Acta       Date:  1976-12-23

4.  Monoclonal antibodies against human lymphocyte antigens.

Authors:  M M Trucco; J W Stocker; R Caeppellini
Journal:  Nature       Date:  1978-06-22       Impact factor: 49.962

5.  Secretion by a hybridoma of antibodies against human alpha-fetoprotein.

Authors:  Y K Tsung; A Milunsky; E Alpert
Journal:  N Engl J Med       Date:  1980-01-17       Impact factor: 91.245

6.  High frequencies of antigen-specific hybridomas: dependence on immunization parameters and prediction by spleen cell analysis.

Authors:  C Stähli; T Staehelin; V Miggiano; J Schmidt; P Häring
Journal:  J Immunol Methods       Date:  1980       Impact factor: 2.303

7.  CEA-like activity in normal colon tissue.

Authors:  G T Rogers; P A Keep
Journal:  Eur J Cancer       Date:  1980-01       Impact factor: 9.162

8.  Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells.

Authors:  H Koprowski; W Gerhard; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

9.  Carcinoembryonic antigen: isolation of a sub-fraction with high specific activity.

Authors:  G T Rogers; F Searle; K D Bagshawe
Journal:  Br J Cancer       Date:  1976-04       Impact factor: 7.640

10.  Extraction of CEA from tumour tissue, foetal colon and patients' sera, and the effect of perchloric acid.

Authors:  P A Keep; B A Leake; G T Rogers
Journal:  Br J Cancer       Date:  1978-02       Impact factor: 7.640
  10 in total
  2 in total

1.  A monoclonal antibody-enzyme immunoassay for serum carcinoembryonic antigen with increased specificity for carcinomas.

Authors:  A Hedin; L Carlsson; A Berglund; S Hammarström
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

2.  Application of monoclonal antibodies to purified CEA in clinical radioimmunoassay of human serum.

Authors:  G T Rogers; G A Rawlins; P A Keep; E H Cooper; K D Bagshawe
Journal:  Br J Cancer       Date:  1981-09       Impact factor: 7.640
  2 in total

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