Literature DB >> 745666

Effect of gamma-glutamyl cycle inhibitors on brain amino acid transport and utilization.

S Samuels, I Fish, L S Freedman.   

Abstract

Two inhibitors of the gamma-glutamyl cycle, methionine sulfoximine (MSO) and 2-imidazolidone-4-carboxylic acid (ICA) were administered to C57LB/6J mice. Both agents resulted in a reduced rate of transport of tyrosine from blood to brain and a decreased rate of incorporation of tyrosine from plasma into brain protein. MSO administration also diminished to concentrations of brain tyrosine, dopamine, and norepinephrine. MSO decreased the transport rate of valine by brain as well as the rate of its incorporation into protein when expressed in relation to the plasma specific activity. The results demonstrate a significant role for the gamma-glutamyl cycle in the transport of large neutral amino acids from blood to brain.

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Year:  1978        PMID： 745666     DOI： 10.1007/bf00963763

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  35 in total

1.  Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats.

Authors:  A G Palekar; S S Tate; A Meister
Journal:  Biochem Biophys Res Commun       Date:  1975-02-03       Impact factor: 3.575

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Journal:  J Lab Clin Med       Date:  1957-11

3.  Rates of exchange of free amino acids between plasma and brain in mice.

Authors:  J Toth; A Lajtha
Journal:  Neurochem Res       Date:  1977-04       Impact factor: 3.996

4.  The fluorometric assay of catecholamines and related compounds: improvements and extensions to the hydroxyindole technique.

Authors:  R Laverty; K M Taylor
Journal:  Anal Biochem       Date:  1968-02       Impact factor: 3.365

5.  Hyperphenylalanaemia and the exchange of tyrosine in adult rat brain.

Authors:  O F Lindroos; S S Oja
Journal:  Exp Brain Res       Date:  1971       Impact factor: 1.972

6.  The gamma-glutamyl cycle: a possible transport system for amino acids.

Authors:  M Orlowski; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1970-11       Impact factor: 11.205

7.  The influx of amino acids into the brain of the rat in vivo: the essential compared with some non-essential amino acids.

Authors:  G Baños; P M Daniel; S R Moorhouse; O E Pratt
Journal:  Proc R Soc Lond B Biol Sci       Date:  1973-02-27

8.  The -glutamyl cycle in the choroid plexus: its possible function in amino acid transport.

Authors:  S S Tate; L L Ross; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1973-05       Impact factor: 11.205

9.  Comparison of turnover rates of proteins of the brain, liver and kidney in mouse in vivo following long term labeling.

Authors:  A Lajtha; L Latzkovits; J Toth
Journal:  Biochim Biophys Acta       Date:  1976-04-02

10.  Identification of L-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine.

Authors:  W B Rowe; A Meister
Journal:  Proc Natl Acad Sci U S A       Date:  1970-06       Impact factor: 11.205
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  7 in total

1.  Compartmentation in the blood-brain barrier: a correction.

Authors:  S Samuels; S A Schwartz
Journal:  Neurochem Res       Date:  1986-11       Impact factor: 3.996

2.  Isolation and purification of multiple forms of gamma-glutamyl transpeptidase from rat brain.

Authors:  E Reyes; T D Barela
Journal:  Neurochem Res       Date:  1980-02       Impact factor: 3.996

3.  Compartmentation in amino acid transport across the blood brain barrier.

Authors:  S Samuels; S A Schwartz
Journal:  Neurochem Res       Date:  1981-07       Impact factor: 3.996

4.  Correlation between carbohydrate and catecholamine level impairments in methionine sulfoximine epileptogenic rat brain.

Authors:  T K Hevor; E Aissi; P Delorme
Journal:  Neurochem Res       Date:  1990-09       Impact factor: 3.996

5.  Age related changes in blood-to-brain amino acid transport and incorporation into brain protein.

Authors:  S Samuels; I Fish; S A Schwartz; U Hochgeschwender
Journal:  Neurochem Res       Date:  1983-02       Impact factor: 3.996

6.  Changes of cerebral gamma glutamyltransferase activities after treatment with exogenous inducers.

Authors:  J F Ghersi-Egea; A Minn; G Siest
Journal:  Neurochem Res       Date:  1987-04       Impact factor: 3.996

7.  Cerebrospinal Fluid Metabolomic Profiles Associated With Fatigue During Treatment for Pediatric Acute Lymphoblastic Leukemia.

Authors:  Austin L Brown; Pagna Sok; Olga Taylor; John P Woodhouse; M Brooke Bernhardt; Kimberly P Raghubar; Lisa S Kahalley; Philip J Lupo; Marilyn J Hockenberry; Michael E Scheurer
Journal:  J Pain Symptom Manage       Date:  2020-09-01       Impact factor: 3.612
  7 in total

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