Literature DB >> 7452316

Hippocampal free amino acids in Alzheimer's disease.

I Tarbit, E K Perry, R H Perry, G Blessed, B E Tomlinson.   

Abstract

The free amino acid content of the hippocampus, obtained at postmortem, has been analysed in cases of Alzheimer's disease and compared with normal cases. There were no significant differences in the levels of 23 amino acids including the transmitter candidates gamma-aminobutyric, glutamic or aspartic acids. This finding is interpreted in relation to present knowledge of transmitter pathways in the region of the hippocampus. A tendency for some amino acids to be increased in the Alzheimer group reached statistical significance for arginine. This observation is consistent with increased proteolytic or peptidase activity in Alzheimer's disease.

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Year:  1980        PMID： 7452316     DOI： 10.1111/j.1471-4159.1980.tb07883.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  9 in total

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Authors:  Leif Hertz; Liang Peng; Dan Song
Journal:  Neurochem Res       Date:  2014-06-15       Impact factor: 3.996

2.  Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction.

Authors:  Jason H Whitfield; William H Zhang; Michel K Herde; Ben E Clifton; Johanna Radziejewski; Harald Janovjak; Christian Henneberger; Colin J Jackson
Journal:  Protein Sci       Date:  2015-08-18       Impact factor: 6.725

3.  High performance liquid chromatography determination of L-glutamate, L-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer's disease.

Authors:  Tommaso Nuzzo; Andrea Mancini; Mattia Miroballo; Alessia Casamassa; Anna Di Maio; Giorgia Donati; Giulia Sansone; Lorenzo Gaetani; Federico Paolini Paoletti; Andrea Isidori; Paolo Calabresi; Francesco Errico; Lucilla Parnetti; Alessandro Usiello
Journal:  Amino Acids       Date:  2021-02-22       Impact factor: 3.520

4.  Alzheimer's disease: amino acid levels and brain metabolic status.

Authors:  Maria Concetta Gueli; Gennaro Taibi
Journal:  Neurol Sci       Date:  2013-01-25       Impact factor: 3.307

5.  Free amino acids in the nervous system of the amphioxus Branchiostoma lanceolatum. A comparative study.

Authors:  Juan Pascual-Anaya; Salvatore D'Aniello
Journal:  Int J Biol Sci       Date:  2006-04-10       Impact factor: 6.580

6.  Stability and Solution Structure of Binary and Ternary Cu(II) Complexes with l-Glutamic Acid and Diamines as Well as Adducts in Metal-Free Systems in Aqueous Solution.

Authors:  Romualda Bregier-Jarzebowska
Journal:  J Solution Chem       Date:  2014-11-26       Impact factor: 1.677

Review 7.  Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease.

Authors:  Karan Govindpani; Beatriz Calvo-Flores Guzmán; Chitra Vinnakota; Henry J Waldvogel; Richard L Faull; Andrea Kwakowsky
Journal:  Int J Mol Sci       Date:  2017-08-21       Impact factor: 5.923

8.  Effect of High-Oleic Peanut Intake on Aging and Its Hippocampal Markers in Senescence-Accelerated Mice (SAMP8).

Authors:  Kiharu Igarashi; Daisuke Kurata
Journal:  Nutrients       Date:  2020-11-11       Impact factor: 5.717

9.  GlyCEST: Magnetic Resonance Imaging of Glycine-Distribution in the Normal Murine Brain and Alterations in 5xFAD Mice.

Authors:  Ken Ohno; Masaki Ohkubo; Bingwen Zheng; Masaki Watanabe; Tsuyoshi Matsuda; Ingrid L Kwee; Hironaka Igarashi
Journal:  Contrast Media Mol Imaging       Date:  2021-12-30       Impact factor: 3.161
  9 in total

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