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Literature DB >> 7452151

Release of endogenous pyrogen-activating factor from concanavalin A-stimulated human lymphocytes.

H A Bernheim, L H Block, L Francis, E Atkins.

Abstract

Evidence is presented that the mitogen concanavalin A stimulates human lymphocytes to produce a nonpyrogenic lymphokine (LK) that is capable of activating human monocytes but not granulocytes to produce endogenous pyrogen (EP) in vitro. The potency of this preparation should facilitate further studies to purify and characterize this agent and determine its relation to other know LK. It seems likely that this factor, which we have called EP-activating factor (EPAF), plays a significant role in the development of fever in states of delayed hypersensitivity in man.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1980 PMID： 7452151 PMCID： PMC2186039 DOI： 10.1084/jem.152.6.1811

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

1. Partial characterization of leukocyte inhibitory factor by concanavalin A-stimulated human lymphocytes (LIF Con A).

Authors: R E Rocklin
Journal: J Immunol Date: 1975-04 Impact factor: 5.422

2. Fever and survival in rabbits infected with Pasteurella multocida.

Authors: M J Kluger; L K Vaughn
Journal: J Physiol Date: 1978-09 Impact factor: 5.182

3. Functional interaction of concanavalin A and bacterial endotoxin (lipopolysaccharide): effects on the measurement of endogenous pyrogen release, human mononuclear cell tissue factor activation, lymphocyte DNA synthesis, and gelation of Limulus amebocyte lysate.

Authors: F R Rickles; J Levin; D I Rosenthal; E Atkins
Journal: J Lab Clin Med Date: 1979-01

4. Fever and survival.

Authors: M J Kluger; D H Ringler; M R Anver
Journal: Science Date: 1975-04-11 Impact factor: 47.728

5. Characterization of human migration inhibitory factor (MIF) from antigen-stimulated lymphocytes.

Authors: R E Rocklin; H G Remold; J R David
Journal: Cell Immunol Date: 1972-11 Impact factor: 4.868

6. Pathogenesis of fever in delayed hypersensitivity: role of monocytes.

Authors: E Atkins; L Francis; H A Bernheim
Journal: Infect Immun Date: 1978-09 Impact factor: 3.441

7. Studies on the mechanism of fever accompanying delayed hypersensitivity. The role of the sensitized lymphocyte.

Authors: E Atkins; J D Feldman; L Francis; E Hursh
Journal: J Exp Med Date: 1972-05-01 Impact factor: 14.307

8. Studies on the mechanism of endogenous pyrogen production. III. Human blood monocytes.

Authors: P Bodel
Journal: J Exp Med Date: 1974-10-01 Impact factor: 14.307

9. Studies on mediator production by highly purified human T and B lymphocytes.

Authors: R E Rocklin; R P MacDermott; L Chess; S F Schlossman; J R David
Journal: J Exp Med Date: 1974-11-01 Impact factor: 14.307

10. Cellular interactions in the proliferative response of human T and B lymphocytes to phytomitogens and allogeneic lymphocytes.

Authors: H P Lohrmann; L Novikovs; R G Graw
Journal: J Exp Med Date: 1974-06-01 Impact factor: 14.307

7 in total

Review 1. Fever in various rheumatic diseases.

Authors: A Weinberger; A Kesler; J Pinkhas
Journal: Clin Rheumatol Date: 1985-09 Impact factor: 2.980

2. Interleukin 1 production by peripheral blood mononuclear cells from leprosy patients.

Authors: S Watson; W Bullock; K Nelson; V Schauf; R Gelber; R Jacobson
Journal: Infect Immun Date: 1984-09 Impact factor: 3.441

3. Chemical characterization of an interleukin-1-inducing substance derived from human mixed leukocyte reactions: IL-1-inducing substance is not gamma interferon.

Authors: C A Dinarello; E F Kent
Journal: Yale J Biol Med Date: 1985 Mar-Apr