Literature DB >> 7451367

Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus.

A Yoshimoto, T Oki, T Takeuchi, H Umezawa.   

Abstract

Baumycin-negative mutants of Streptomyces coeruleorubidus ME130-A4 do not convert daunomycinone to daunomycin and baumycins. They biosynthesize daunomycin from aklavinone and epsilon-rhodomycinone, indicating the glycosidation of the aglycone before the synthesis of daunomycinone. The biosynthetic pathway from epsilon-rhodomycinone to daunomycin was further confirmed by studying the bioconversion of anthracyclinones and anthracyclines, which are presumed to be intermediates.

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Year:  1980        PMID： 7451367     DOI： 10.7164/antibiotics.33.1158

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

Review 1.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

2.  Multigene families for anthracycline antibiotic production in Streptomyces peucetius.

Authors:  K J Stutzman-Engwall; C R Hutchinson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

Review 3.  Streptomycetes producing daunomycin and related compounds: do we know enough about them after 25 years?

Authors:  J Huk; M Blumauerova
Journal:  Folia Microbiol (Praha)       Date:  1989       Impact factor: 2.099

4.  Biosynthetic relationships among daunorubicin, doxorubicin and 13-dihydrodaunorubicin in Streptomyces peucetius.

Authors:  N Crespi-Perellino; A Grein; S Merli; A Minghetti; C Spalla
Journal:  Experientia       Date:  1982-12-15

5.  In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.

Authors:  M L Dickens; N D Priestley; W R Strohl
Journal:  J Bacteriol       Date:  1997-04       Impact factor: 3.490

6.  Expression of doxorubicin-daunorubicin resistance genes in different anthracycline-producing mutants of Streptomyces peucetius.

Authors:  A L Colombo; M M Solinas; G Perini; G Biamonti; G Zanella; M Caruso; F Torti; S Filippini; A Inventi-Solari; L Garofano
Journal:  J Bacteriol       Date:  1992-03       Impact factor: 3.490

7.  Novel aromatic polyketides from soil Streptomyces spp.: purification, characterization and bioactivity studies.

Authors:  Sunita Bundale; Deovrat Begde; Dhanashree Pillai; Karishma Gangwani; Nandita Nashikkar; Tukaram Kadam; Avinash Upadhyay
Journal:  World J Microbiol Biotechnol       Date:  2018-04-24       Impact factor: 3.312
  7 in total

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