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Literature DB >> 7450773

Prevention of chromosomal breakage in Fanconi's anemia by cocultivation with normal cells.

Abstract

The frequency of aberrations in cultured lymphocytes from patients with Fanconi's anemia was significantly reduced when the cells were cocultivated with normal human lymphocytes. The results suggest that most of the chromosomal aberrations observed in cultured cells from Fanconi patients arise during cultivation and that the presence of normal cells prevents chromosomal damage by means of a hitherto unknown mechanism.

Entities: Disease Species

Mesh：

Year: 1980 PMID： 7450773 DOI： 10.1007/bf00295689

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

12 in total

1. Is Fanconi's anaemia defective in a process essential to the repair of DNA cross links?

Authors: M S Sasaki
Journal: Nature Date: 1975-10-09 Impact factor: 49.962

2. The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to trenimon-induced aberrations in human lymphocytes and fibroblasts.

Authors: K Hayashi; W Schmid
Journal: Humangenetik Date: 1975-09-23

3. Progeria cells are stimulated to repair DNA by co-cultivation with normal cells.

Authors: W T Brown; J Epstein; J B Little
Journal: Exp Cell Res Date: 1976-02 Impact factor: 3.905

4. Effect of superoxide dismutase and catalase on spontaneously occurring chromosome breaks in patients with Fanconi's anemia.

Authors: I Nordenson
Journal: Hereditas Date: 1977 Impact factor: 3.271

5. Nonrandom distribution of chromosome breaks in Fanconi's anemia.

Authors: H Von Koskull; P Aula
Journal: Cytogenet Cell Genet Date: 1973

6. [Chromosome abnormalities in constitutional cytopenia].

Authors: D Germain; C Requin
Journal: Nouv Rev Fr Hematol Date: 1970 Jan-Feb

7. Erythrocyte superoxide-dismutase deficiency in Fanconi's anaemia.

Authors: H Joenje; A W Eriksson; R R Frants; F Arwert; B Houwen
Journal: Lancet Date: 1978-01-28 Impact factor: 79.321

8. Frequency and distribution of sister-chromatid exchanges in a case of Fanconi's anemia.

Authors: K Sperling; R D Wegner; H Riehm; G Obe
Journal: Humangenetik Date: 1975

9. Leukocytes cultured from small inocula of whole blood and the preparation of metaphase chromosomes by treatment with hypotonic KCl.

Authors: D A Hungerford
Journal: Stain Technol Date: 1965-11

10. Chromosome abnormalities in constitutional aplastic anemia.

Authors: G E Bloom; S Warner; P S Gerald; L K Diamond
Journal: N Engl J Med Date: 1966-01-06 Impact factor: 91.245

7 in total

1. Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. I. Involvement of interleukin-6.

Authors: F Rosselli; J Sanceau; J Wietzerbin; E Moustacchi
Journal: Hum Genet Date: 1992-04 Impact factor: 4.132

2. Cocultivation of Fanconi anemia cells and of mouse lymphoma mutants leads to interspecies complementation of chromosomal hypersensitivity to DNA cross-linking agents.

Authors: F Rosselli; E Moustacchi
Journal: Hum Genet Date: 1990-05 Impact factor: 4.132

3. Antagonistic effect of cocultivation on mitomycin C-induced aberration rate in cells of a patient with Fanconi's anemia and in Chinese hamster ovary cells.

Authors: S Zakrzewski; K Sperling
Journal: Hum Genet Date: 1980 Impact factor: 4.132