Radiopaque contrast media. XLVI - Preliminary studies of the metabolism of iopamidol in the dog, the rabbit and man.

Alter its intravenous injection in dogs and rabbits, Iopamidol was excreted almost exclusively by the kidneys. In both urine and bile, the only iodinated compound found by either TLC or HPLC was Iopamidol. Similar results were obtained after the injection of Iopamidol into the spinal subarachnoid space of rabbits. Preliminary studies in man showed that the compound was excreted unmetabolized. No racemization occurred during absorption, distribution or excretion of the contrast medium.