Literature DB >> 7447425

Stimulation of leucomycin production by magnesium phosphate and its relevance to nitrogen catabolite regulation.

S Omura, Y Tanaka, C Kitao, H Tanaka, Y Iwai.   

Abstract

Addition of magnesium phosphate [Mg3(PO4)2 x 8H2O] to a complex medium or to an ammonium ion-containing, chemically defined medium stimulated leucomycin production by Streptomyces kitasatoensis. Ammonium ions in high concentrations inhibited leucomycin production, but their limitation by magnesium phosphate led to the high production of the antibiotic.

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Year:  1980        PMID： 7447425      PMCID： PMC284077          DOI： 10.1128/AAC.18.5.691

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Chemical and biological studies on 16-membered macrolide antibiotics.

Authors:  S Omura; A Nakagawa
Journal:  J Antibiot (Tokyo)       Date:  1975-06       Impact factor: 2.649

2.  Effect of aeration on the novobiocin fermentation.

Authors:  C G SMITH
Journal:  Appl Microbiol       Date:  1960-01

3.  Observations on Streptomyces griseus: II. Nitrogen Sources for Growth and Streptomycin Production.

Authors:  E L Dulaney
Journal:  J Bacteriol       Date:  1948-09       Impact factor: 3.490

4.  Relationship between fatty-acid and phenol synthesis in Aspergillus fumigatus.

Authors:  A C Ward; N M Packter
Journal:  Eur J Biochem       Date:  1974-07-15

Review 5.  Effect of primary metabolites on secondary metabolism.

Authors:  S W Drew; A L Demain
Journal:  Annu Rev Microbiol       Date:  1977       Impact factor: 15.500

6.  [Study of the growth patterns of Act. antibioticus and the biosynthesis of oleandomycin].

Authors:  E I Surikova; L M Novikova; T M Gerasimova
Journal:  Antibiotiki       Date:  1976-03

7.  Nitrogen nutrition and regulation of cephalosporin production in Streptomyces clavuligerus.

Authors:  Y Aharonowitz; A L Demain
Journal:  Can J Microbiol       Date:  1979-01       Impact factor: 2.419

8.  Letter: Biosynthetic studies using 13C enriched precursors on the 16-membered macrolide antibiotic leucomycin A3.

Authors:  S Omura; A Nakagawa; H Takeshima; K Atusmi; J Miyazawa; F Piriou; G Lukacs
Journal:  J Am Chem Soc       Date:  1975-10-29       Impact factor: 15.419

9.  [Characteristics of fucidin biosynthesis by a Fusidium coccineum 257 A strain].

Authors:  G A Penzikova; N E Sepanova; M M Levitov
Journal:  Antibiotiki       Date:  1977-01
  9 in total
  3 in total

Review 1.  Philosophy of new drug discovery.

Authors:  S Omura
Journal:  Microbiol Rev       Date:  1986-09

2.  Ammonium effects on streptonigrin biosynthesis by Streptomyces flocculus.

Authors:  K K Wallace; G F Payne; M K Speedie
Journal:  J Ind Microbiol       Date:  1990-09

3.  Effect of ammonium ions on spiramycin biosynthesis in Streptomyces ambofaciens.

Authors:  A Lebrihi; D Lamsaif; G Lefebvre; P Germain
Journal:  Appl Microbiol Biotechnol       Date:  1992-06       Impact factor: 4.813
  3 in total

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