Literature DB >> 7446314

Endogenous inhibitor of prostaglandin biosynthesis in inflammation.

M Di Rosa, F Capasso, N Mascolo.   

Abstract

Rat serum exhibits a concentration-related inhibition of PG biosynthesis by rat peritoneal leucocytes phagocytosing killed bacteria. The serum inhibitory potency is increased by inducing carrageenan foot oedema in animals whereas it is not altered by dextran oedema. The increase of the inhibitory activity of serum from carrageenan-treated rats develops in a time-dependent way reaching its maximum at 24 h. Since the increased inhibitory activity does not occur following indomethacin administration we suggest that PG formation at the inflammatory site may stimulate the ability of serum to inhibit PG biosynthesis.

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Year:  1980        PMID： 7446314     DOI： 10.1007/bf01971440

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  Increase in serum haptoglobin stimulated by prostaglandins.

Authors:  B S Shim
Journal:  Nature       Date:  1976-01-29       Impact factor: 49.962

2.  A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis.

Authors:  G A Higgs; E McCall; L J Youlten
Journal:  Br J Pharmacol       Date:  1975-04       Impact factor: 8.739

3.  Potential endogenous inhibitor of prostaglandin synthetase in plasma: failure to inhibit cyclo-oxygenase in platelets and the gastric mucosa.

Authors:  B J Whittle
Journal:  J Pharm Pharmacol       Date:  1978-07       Impact factor: 3.765

4.  Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.

Authors:  M Di Rosa; J P Giroud; D A Willoughby
Journal:  J Pathol       Date:  1971-05       Impact factor: 7.996

5.  Prostaglandins released by the spleen.

Authors:  N Gilmore; J R Vane; J H Wyllie
Journal:  Nature       Date:  1968-06-22       Impact factor: 49.962

6.  Glucocorticosteroids, prostaglandins and the inflammatory process.

Authors:  L Parente; G Ammendola; P Persico; M di Rosa
Journal:  Pol J Pharmacol Pharm       Date:  1978 Mar-Jun

7.  Inhibition by various substances of oedema formation in the bind-paw of the rat induced by 5-hydroxytryptamine, histamine, dextran, egg-white and compound 48/80.

Authors:  J R PARRATT; G B WEST
Journal:  Br J Pharmacol Chemother       Date:  1958-03

8.  Endogenous inhibitor of prostaglandin synthetase.

Authors:  S A Saeed; W J McDonald-Gibson; J Cuthbert; J L Copas; C Schneider; P J Gardiner; N M Butt; H O Collier
Journal:  Nature       Date:  1977-11-03       Impact factor: 49.962

9.  Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol).

Authors:  R J Flower; J R Vane
Journal:  Nature       Date:  1972-12-15       Impact factor: 49.962

10.  A sensitive method for the assay of 5-hydroxytryptamine.

Authors:  J R VANE
Journal:  Br J Pharmacol Chemother       Date:  1957-09
  10 in total

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