Literature DB >> 74391

Antigenicity of the major polypeptides of hepatitis B surface antigen (HBsAg).

J W Shih, P L Tan, J L Gerin.   

Abstract

The major polypeptides (P-1, P-2, and P-6) of HBsAg were isolated from purified preparations of 22-nm HBsAg particles, iodinated, and analyzed by double-antibody radioimmunoprecipitation assays for the presence of hepatitis B virus (HBV)-specific antigens. Each polypeptide fraction contained both group (a) and subtype (d) specific determinants in common by virtue of their immunoreaction with antiserum to native HBsAg and antisera to the other structural polypeptides. The antigenic and structural similarities of the HBsAg polypeptides establish that they are not each unique gene products of the HBV genome.

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Year:  1978        PMID： 74391

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  9 in total

1.  Surface antigenic determinants of mammalian "hepadnaviruses" defined by group- and class-specific monoclonal antibodies.

Authors:  P J Cote; G M Dapolito; J W Shih; J L Gerin
Journal:  J Virol       Date:  1982-04       Impact factor: 5.103

2.  Hepatitis B surface antigen polypeptides: artifactual bands in sodium dodecyl sulfate-polyacrylamide gel electrophoresis caused by aggregation.

Authors:  V U Koistinen
Journal:  J Virol       Date:  1980-07       Impact factor: 5.103

3.  Relationship of large hepatitis B surface antigen polypeptide to human serum albumin.

Authors:  J W Shih; P L Tan; J L Gerin
Journal:  Infect Immun       Date:  1980-05       Impact factor: 3.441

4.  Characterization of antigen moiety of HBsAg in the complement fixing immune complexes of hepatitis B virus positive chronic active hepatitis.

Authors:  R C Gupta
Journal:  Clin Exp Immunol       Date:  1982-09       Impact factor: 4.330

5.  Nonoverlapping antigenic sites of woodchuck hepatitis virus surface antigen and their cross-reactivity with ground squirrel hepatitis virus and hepatitis B virus surface antigens.

Authors:  P J Cote; J L Gerin
Journal:  J Virol       Date:  1983-07       Impact factor: 5.103

6.  Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.

Authors:  J L Gerin; H Alexander; J W Shih; R H Purcell; G Dapolito; R Engle; N Green; J G Sutcliffe; T M Shinnick; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

7.  Hepatitis B surface antigen. Role of lipids in maintaining the structural and antigenic properties of protein components.

Authors:  F Gavilanes; J Gomez-Gutierrez; M Aracil; J M Gonzalez-Ros; J A Ferragut; E Guerrero; D L Peterson
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

8.  Immunization of chimpanzees with hepatitis B virus-derived polypeptides.

Authors:  G R Dreesman; F B Hollinger; Y Sanchez; P Oefinger; J L Melnick
Journal:  Infect Immun       Date:  1981-04       Impact factor: 3.441

9.  Expression of the hepatitis B virus surface antigen gene in cell culture by using a simian virus 40 vector.

Authors:  A M Moriarty; B H Hoyer; J W Shih; J L Gerin; D H Hamer
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205
  9 in total

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