Literature DB >> 7424908

Genetic polymorphism of human plasminogen.

D Raum, D Marcus, C A Alper.   

Abstract

Using isoelectric focusing (IEF) in polyacrylamide gel of neuraminidase-treated serum or plasma samples and immunofixation or caseinolytic overlay after urokinase activation of gels, a common genetic polymorphism in human plasminogen has been delineated. Two alleles PLGN*A and PLGN*B, were observed with gene frequencies in whites of .69 and .30; in Orientals of .96 and .03; and in blacks of .80 and .18. Several rare alleles were also found. The distribution of phenotypes fits the Hardy-Weinberg equilibrium. Inheritance is autosomal codominant and fits the expectations of Mendelian inheritance. There is fetal synthesis, but no transplacental passage of plasminogen in either direction.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7424908      PMCID： PMC1686101     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  17 in total

1.  NH2-terminal sequences of mammalian plasminogens and plasmin S-carboxymethyl heavy (A) and light (B) chain derivatives. A re-evaluation of the mechanism of activation of plasminogen.

Authors:  K C Robbins; P Bernabe; L Arzadon; L Summaria
Journal:  J Biol Chem       Date:  1973-10-25       Impact factor: 5.157

2.  The primary structure of human plasminogen. I. The NH 2 -terminal sequences of human plasminogen and the S-carboxymethyl heavy (A) and light (B) chain derivatives of plasmin.

Authors:  K C Robbins; P Bernabe; L Arzadon; L Summaria
Journal:  J Biol Chem       Date:  1972-11-10       Impact factor: 5.157

3.  Studies on the isolation of the multiple molecular forms of human plasminogen and plasmin by isoelectric focusing methods.

Authors:  L Summaria; L Arzadon; P Bernabe; K C Robbins
Journal:  J Biol Chem       Date:  1972-07-25       Impact factor: 5.157

4.  Characterization of human plasminogen. II. Separation and partial characterization of different molecular forms of human plasminogen.

Authors:  P Wallén; B Wiman
Journal:  Biochim Biophys Acta       Date:  1972-01-26

5.  Isoelectric focusing in polyacrylamide gel and its application to immunoglobulins.

Authors:  Z L Awdeh; A R Williamson; B A Askonas
Journal:  Nature       Date:  1968-07-06       Impact factor: 49.962

6.  Characterization of the NH 2 -terminal glutamic acid and NH 2 -terminal lysine forms of human plasminogen isolated by affinity chromatography and isoelectric focusing methods.

Authors:  L Summaria; L Arzadon; P Bernabe; K C Robins
Journal:  J Biol Chem       Date:  1973-05-10       Impact factor: 5.157

7.  Measurement of the binding of antifibrinolytic amino acids to various plasminogens.

Authors:  W J Brockway; F J Castellino
Journal:  Arch Biochem Biophys       Date:  1972-07       Impact factor: 4.013

8.  Plasminogen: purification from human plasma by affinity chromatography.

Authors:  D G Deutsch; E T Mertz
Journal:  Science       Date:  1970-12-04       Impact factor: 47.728

9.  Physical and chemical properties of the NH2-terminal glutamic acid and lysine forms of human plasminogen and their derived plasmins with an NH2-terminal lysine heavy (A) chain.

Authors:  K C Robbins; I G Boreisha; L Arzadon; L Summaria
Journal:  J Biol Chem       Date:  1975-06-10       Impact factor: 5.157

10.  De novo biosynthesis of plasminogen in the anephric rat.

Authors:  G E Siefring; F J Castellino
Journal:  J Appl Physiol       Date:  1975-01       Impact factor: 3.531
View more
  15 in total

1.  Plasminogen with type-I mutation is polymorphic in the Japanese population.

Authors:  S Kikuchi; Y Yamanouchi; L Li; K Kobayashi; H Ijima; R Miyazaki; S Tsuchiya; H Hamaguchi
Journal:  Hum Genet       Date:  1992 Sep-Oct       Impact factor: 4.132

2.  PLG A91 and PLG M6: two new plasminogen allotypes in Japan.

Authors:  I Yuasa; K Suenaga; K Iijima; C Fukuda; K Umetsu; K Okada
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

3.  Further evidence of a silent plasminogen (PLG) allele in two paternity cases.

Authors:  S Weidinger; W Patutschnick; F Schwarzfischer
Journal:  Z Rechtsmed       Date:  1988

4.  Complotype genetic loci segregate more frequently with HLA-DR than with HLA-B.

Authors:  E J Yunis; Z Awdeh; A Johnson; N Suciu-Foca; M A Robinson; R Hartzman; D Raum; E Fleischnick; C A Alper
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

5.  Genetic polymorphism of human factor I (C3b inactivator).

Authors:  S Nakamura; K Abe
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

6.  Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

Authors:  J C Murray; K H Buetow; M Donovan; S Hornung; A G Motulsky; C Disteche; K Dyer; K Swisshelm; J Anderson; E Giblett
Journal:  Am J Hum Genet       Date:  1987-04       Impact factor: 11.025

7.  Differences of frequency distributions of plasminogen phenotypes between Japanese and American populations: new methods for the detection of plasminogen variants.

Authors:  N Aoki; K Tateno; Y Sakata
Journal:  Biochem Genet       Date:  1984-10       Impact factor: 1.890

8.  The polymorphism of plasminogen (PLG) by ultrathin-layer isoelectric focusing. Distribution in the Veneto population (Italy).

Authors:  P Cortivo; L Caenazzo; C Crestani; C Scorretti; P Benciolini; E Pornaro
Journal:  Z Rechtsmed       Date:  1986

9.  The plasminogen polymorphism in South African Negro populations: genetics and anthropogenetics.

Authors:  H W Hitzeroth; U Skoda; E du Toit; G Mauff
Journal:  Hum Genet       Date:  1986-12       Impact factor: 4.132

10.  Plasminogen (PLG): a useful genetic marker for paternity examinations.

Authors:  S Weidinger; F Schwarzfischer; H Müller; H Cleve
Journal:  Z Rechtsmed       Date:  1985
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.