| Literature DB >> 7422003 |
A Klug, D Rhodes, J Smith, J T Finch, J O Thomas.
Abstract
Image reconstruction to 22 A resolution of the histone octamer (H3)2(H4)2(H2A)2(H2B)2 shows it to have a 2-fold axis of symmetry, and the overall shape of the left-handed helical spool on which to wind about two turns of a flat superhelix of DNA in the nucleosome. From this structure and the results of various cross-linking studies, we have deduced the arrangement of the individual histones. We propose that the (H3)2(H4)2 tetramer forms a dislocated disk which defines the central turn of DNA, while the two H2A-H2B dimers lie one on each face, each associated with about one half a turn.Mesh：
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Year: 1980 PMID： 7422003 DOI： 10.1038/287509a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962