Literature DB >> 7420294

Fluorometric high-performance liquid chromatographic determination of sotalol in biological fluids.

M A Lefebvre, J Girault, M C Saux, J B Fourtillan.   

Abstract

A high-performance liquid chromatographic (HPLC) method for sotalol in biological fluids is presented. Sample preparation involves a simple acid-base double-extraction procedure, and analysis is carried out on a reversed-phase chromatographic system using a muBondapak C18 column. Procainamide was used as the internal standard. As little as 20 ng of sotalol/ml can be detected with good precision by a fluorometric detector. HPLC, which allows more rapid analysis of plasma sotalol levels than does GLC, appears suitable for pharmacokinetic studies as well as for therapeutic drug monitoring.

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Year:  1980        PMID： 7420294     DOI： 10.1002/jps.2600691026

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  3 in total

Review 1.  Sotalol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use.

Authors:  B N Singh; P Deedwania; K Nademanee; A Ward; E M Sorkin
Journal:  Drugs       Date:  1987-09       Impact factor: 9.546

2.  Pharmacokinetics of a fixed combination of sotalol and hydrochlorothiazide in hypertensive patients with moderate renal insufficiency.

Authors:  A Kher; J P Fillastre; J B Fourtillan; M A Lefebvre; I Ingrand
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

3.  A comparison of the cardiovascular effects of (+)-sotalol and (+/-)-sotalol following intravenous administration in normal volunteers.

Authors:  G D Johnston; M B Finch; J A McNeill; R G Shanks
Journal:  Br J Clin Pharmacol       Date:  1985-11       Impact factor: 4.335
  3 in total

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