Literature DB >> 7418808

Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice.

H S Zackheim, E A Smuckler.   

Abstract

Mice were painted with mechlorethamine (HN2), carmustine (BCNU) and lomustine (CCNU) for up to 33 weeks. HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series. BCNU was a weak carcinogen. CCNU produced no tumors in 1 series.

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Year:  1980        PMID： 7418808     DOI： 10.1007/bf01976135

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Comparative late somatic effects of some radiomimetic agents and x-rays.

Authors:  J W CONKLIN; A C UPTON; K W CHRISTENBERRY; T P McDONALD
Journal:  Radiat Res       Date:  1963-05       Impact factor: 2.841

2.  Occurrence of tumors in mice injected subcutaneously with sulfur mustard and nitrogen mustard.

Authors:  W E HESTON
Journal:  J Natl Cancer Inst       Date:  1953-08       Impact factor: 13.506

3.  Treatment of mycosis fungoides with topical BCNU.

Authors:  H S Zackheim; E H Epstein; D A Grekin
Journal:  Cancer Treat Rep       Date:  1979-04

4.  [Carcinogenic action of nitrogen mustard; experimental research].

Authors:  A NARPOZZI
Journal:  Riv Anat Patol Oncol       Date:  1953-05

5.  Bioassay program for carcinogenic hazards of cancer chemotherapeutic agents.

Authors:  E K Weisburger
Journal:  Cancer       Date:  1977-10       Impact factor: 6.860

6.  Mycosis fungoides, nitrogen mustard and skin cancer.

Authors:  A Du Vivier; E C Vonderheid; E J Van Scott; F Urbach
Journal:  Br J Dermatol       Date:  1978-07       Impact factor: 9.302

7.  Topical nitrogen mustard induced carcinogenesis.

Authors:  P H Kravitz; C J McDonald
Journal:  Acta Derm Venereol       Date:  1978       Impact factor: 4.437
  7 in total
  1 in total

1.  Inhibition of bcl-2 and cox-2 Protein Expression after Local Application of a New Carmustine-Loaded Clinoptilolite-Based Delivery System in a Chemically Induced Skin Cancer Model in Mice.

Authors:  Cristina Mihaela Ghiciuc; Aurel Lulu Strat; Lacramioara Ochiuz; Catalina Elena Lupusoru; Maria Ignat; Aurelia Vasile; Alexandru Grigorovici; Iulian Stoleriu; Carmen Solcan
Journal:  Molecules       Date:  2017-11-20       Impact factor: 4.411
  1 in total

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