Literature DB >> 7417876

[S-adenosyl-L-homocysteine: 2. An anticonvulsant].

P Fonlupt, M Roche, A C Andre, L Cronenberger, H Pacheco.   

Abstract

S-Adenosyl-L-homocysteine (SAH) decreases the epileptiform discharges induced by hippocampic stimulation. SAH reduces the pentetrazol convulsions, does not modify picrotoxine convulsions, and increases strychnine toxicity. These effects are not linked to gamma-aminobutyric acid metabolism perturbation or to the concentration of some amino acids known for their action in synaptic transmission.

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Year:  1980        PMID: 7417876

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN: 0008-4212            Impact factor:   2.273


  2 in total

1.  Down-regulation of S-adenosylhomocysteine hydrolase in the active methyl transfer system in the brain of genetically epileptic El mice.

Authors:  O Ohmori; H Hirano; T Ono; K Abe; T Mita
Journal:  Neurochem Res       Date:  1996-10       Impact factor: 3.996

2.  Pharmacokinetics and metabolism of S-adenosyl-L-homocysteine, in rats and dog.

Authors:  A Gharib; N Sarda; B Chabannes; H Pacheco
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1985 Oct-Dec       Impact factor: 2.441

  2 in total

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