Pharmacokinetics and metabolism of S-adenosyl-L-homocysteine, in rats and dog.

Tissue distribution, metabolism and excretion of 14C-S-adenosyl-L-homocyteine were investigated in rat after oral and intraperitoneal administration. The radioactivity was distributed rapidly to the tissues. The urine was the major route of excretion: respectively 32% and 52% of radioactivity were excreted in 48 h urine after oral and intraperitoneal administration. Analysis of urine by HPLC showed that the major part of the radioactivity could be identified as uric acid. Absorption and pharmacokinetic parameters were determined in dog after oral and intravenous administration. The experimental data were fitted to a biexponential equation from a two-compartment open model.