Literature DB >> 7417797

Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens.

C Y Yim, G J Mogenson.   

Abstract

Electrical stimulation of nucleus accumbens inhibited the activity of neurons in the ventral tegmental area (VTA). Inhibition was potentiated by nipecotic acid, a GABA uptake inhibitor, and was attenuated by picrotoxin, a GABA antagonist. Four units inhibited by nucleus accumbens stimulation were also antidromically activated. These observations suggest that neurons in the VTA, including specifically those projecting to the nucleus accumbens, receive a descending GABAergic input from that area.

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Year:  1980        PMID： 7417797     DOI： 10.1016/0006-8993(80)90705-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area.

Authors:  D A Lane; A Jaferi; M J Kreek; V M Pickel
Journal:  Neuroscience       Date:  2010-05-27       Impact factor: 3.590

Review 2.  Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART).

Authors:  Kenneth Blum; Thomas J H Chen; B William Downs; Abdalla Bowirrat; Roger L Waite; Eric R Braverman; Margaret Madigan; Marlene Oscar-Berman; Nicholas DiNubile; Eric Stice; John Giordano; Siobhan Morse; Mark Gold
Journal:  Postgrad Med       Date:  2009-11       Impact factor: 3.840

3.  Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats.

Authors:  Jordan M Blacktop; Oliver Vranjkovic; Matthieu Mayer; Matthew Van Hoof; David A Baker; John R Mantsch
Journal:  Neuropharmacology       Date:  2015-11-17       Impact factor: 5.250

4.  GABAergic mechanisms within the ventral tegmental area: involvement of dopaminergic (A 10) and non-dopaminergic neurones.

Authors:  L Stinus; J P Herman; M Le Moal
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

5.  Ventral Tegmental Area Microinjected-SKF38393 Increases Regular Chow Intake in 18 Hours Food-Deprived Rats.

Authors:  Farzaneh Saebi Rad; Abbas Haghparast; Afsaneh Eliassi
Journal:  Basic Clin Neurosci       Date:  2020-11-01

6.  Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons.

Authors:  Zengpeng Han; Nengsong Luo; Jiaxin Kou; Lei Li; Zihong Xu; Siyuan Wei; Yang Wu; Jie Wang; Chaohui Ye; Kunzhang Lin; Fuqiang Xu
Journal:  Mol Brain       Date:  2022-01-29       Impact factor: 4.041

Review 7.  VTA GABA Neurons at the Interface of Stress and Reward.

Authors:  Chloé Bouarab; Brittney Thompson; Abigail M Polter
Journal:  Front Neural Circuits       Date:  2019-12-05       Impact factor: 3.492
  7 in total

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