Literature DB >> 7408965

The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation.

G A Higgs, K E Eakins, K G Mugridge, S Moncada, J R Vane.   

Abstract

Some non-steroid anti-inflammatory drugs which inhibit arachidonate cyclo-oxygenease have been examined for their effects on leukocyte migration, prostaglandin production and oedema formation in carrageenin-induced inflammation in the rat. At doses which inhibited oedema, all the drugs tested caused a dose-dependent reduction in numbers of leukocytes and prostaglandin concentrations in 24-h inflammatory exudates. At lower doses, indomethacin, aspirin, sodium salicylate, flurbiprofen and phenylbutazone significantly potentiated leukocyte migration by 20-70%. Ibuprofen, naproxen and BW755C reversed the indomethacin-induced increase in leukocyte accumulation. BW755C inhibits the generation of chemotactic lipoxygenase products and it is possible that the effects of all these drugs on leukocyte migration are mediated through the lipoxygenase pathway of arachidonic acid metabolism.

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Year:  1980        PMID： 7408965     DOI： 10.1016/0014-2999(80)90297-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  42 in total

1.  A neutrophil-derived cytochrome P450-dependent metabolite of arachidonic acid modulates neutrophil behavior.

Authors:  R Kraemer; M M Bednar; M A Hatala; K M Mullane
Journal:  Am J Pathol       Date:  1987-09       Impact factor: 4.307

2.  Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493.

Authors:  D E Griswold; S Hoffstein; P J Marshall; E F Webb; L Hillegass; P E Bender; N Hanna
Journal:  Inflammation       Date:  1989-12       Impact factor: 4.092

3.  Molecular docking and pharmacological/toxicological assessment of a new compound designed from celecoxib and paracetamol by molecular hybridization.

Authors:  Daiany P B da Silva; Iziara F Florentino; Dayane M da Silva; Roberta C Lino; Carina S Cardoso; Lorrane K S Moreira; Géssica A Vasconcelos; Daniela C Vinhal; Anna C D Cardoso; Bianca Villavicencio; Hugo Verli; Boniek G Vaz; Luciano M Lião; Luiz C da Cunha; Ricardo Menegatti; Elson A Costa
Journal:  Inflammopharmacology       Date:  2018-07-23       Impact factor: 4.473

4.  In vitro and in vivo impact of a new glycosphingolipid on neutrophils.

Authors:  E Tubaro; C Croce; G Cavallo; L Belogi; G Guida; C Santiangeli; M G Cifone; A Santoni; F Mainiero
Journal:  Agents Actions       Date:  1994-10

5.  The effects of acetylsalicylic acid on swelling, pain and other events after surgery.

Authors:  P Skjelbred
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

6.  Inflammation in the rat paw due to urate crystals. Involvement of the kinin system.

Authors:  J Damas; G Remacle-Volon; A Adam
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-01       Impact factor: 3.000

7.  Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C.

Authors:  G A Higgs; K G Mugridge; S Moncada; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

8.  Role of lipoxygenase products in murine pulmonary granuloma formation.

Authors:  S L Kunkel; S W Chensue; C Mouton; G I Higashi
Journal:  J Clin Invest       Date:  1984-08       Impact factor: 14.808

9.  Antiinflammatory properties of a hydroperoxide compound, structurally related to acetylsalicylic acid.

Authors:  J J Killackey; B A Killackey; I Cerskus; R B Philp
Journal:  Inflammation       Date:  1984-06       Impact factor: 4.092

10.  Antiinflammatory Activity of Aqueous Extract of Stereospermum kunthianum (Cham, Sandrine Petit) Stem Bark in Rats.

Authors:  F P Ching; E K I Omogbai; S O Okpo; R I Ozolua
Journal:  Indian J Pharm Sci       Date:  2009-01       Impact factor: 0.975
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