Literature DB >> 2559032

Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493.

D E Griswold1, S Hoffstein, P J Marshall, E F Webb, L Hillegass, P E Bender, N Hanna.   

Abstract

The mode of action of the dual inhibitors of eicosanoid metabolism, SK&F 86002 and SK&F 104493 was evaluated on inflammatory cell infiltration induced in mice by carrageenan, monosodium urate crystals, and arachidonic acid. The results were compared to those seen with standard antiinflammatory compounds. Inflammatory cell infiltration was inhibited by SK&F 86002. SK&F 104493, colchicine, and phenidone but not naproxen. In vivo, PMN infiltration induced by LTB4 was inhibited by colchicine but not by SK&F 86002, SK&F 104493, or phenidone treatment. Similarly, in vitro chemotaxis to LTB4 was not inhibited by SK&F 86002. The 5-lipoxygenase inhibitors, SK&F 86002, SK&F 104493, and phenidone inhibited LTB4 production in vivo as well as inflammatory cell infiltration induced by arachidonic acid. The data are consistent with the suggestion that the bicyclic imidazoles inhibit PMN infiltration by virtue of inhibition of LTB4 production.

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Year:  1989        PMID： 2559032     DOI： 10.1007/BF00914315

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  25 in total

1.  Pharmacologic characterization of the antiinflammatory properties of a new dual inhibitor of lipoxygenase and cyclooxygenase.

Authors:  M J DiMartino; D E Griswold; B A Berkowitz; G Poste; N Hanna
Journal:  Agents Actions       Date:  1987-02

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Journal:  Lancet       Date:  1983-02-19       Impact factor: 79.321

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Authors:  G A Higgs
Journal:  Prog Lipid Res       Date:  1986       Impact factor: 16.195

4.  Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses.

Authors:  G A Higgs; R L Follenfant; L G Garland
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739

5.  Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes.

Authors:  J D Levine; W Lau; G Kwiat; E J Goetzl
Journal:  Science       Date:  1984-08-17       Impact factor: 47.728

6.  Arachidonate metabolic pathways in cells harvested from rat pleural cavity at various times after carrageenan administration.

Authors:  H L White; L D Faison; J F Truax; J L Selph; R Vinegar
Journal:  Prostaglandins Leukot Med       Date:  1985-10

7.  Modulation of mouse ear edema by cyclooxygenase and lipoxygenase inhibitors and other pharmacologic agents.

Authors:  R P Carlson; L O'Neill-Davis; J Chang; A J Lewis
Journal:  Agents Actions       Date:  1985-12

8.  Species difference in increased vascular permeability by synthetic leukotriene C4 and D4.

Authors:  A Ueno; K Tanaka; M Katori; M Hayashi; Y Arai
Journal:  Prostaglandins       Date:  1981-04

9.  Fibonectin is a component of the surface coat of human neutrophils.

Authors:  S T Hoffstein; G Weissmann; E Pearlstein
Journal:  J Cell Sci       Date:  1981-08       Impact factor: 5.285

10.  Crystal-induced inflammation in canine joints. I. An experimental model with quantification of the host response.

Authors:  D J McCarty; P Phelps; J Pyenson
Journal:  J Exp Med       Date:  1966-07-01       Impact factor: 14.307
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  4 in total

1.  Reduced endotoxin-induced production of tumor necrosis factor activity by equine peritoneal macrophages exposed to the dual inhibitor of arachidonic acid metabolism, SK & F 86002.

Authors:  D D Morris; N Crowe; J N Moore
Journal:  Can J Vet Res       Date:  1992-04       Impact factor: 1.310

2.  Induction of plasma exudation and inflammatory cell infiltration by leukotriene C4 and leukotriene B4 in mouse peritonitis.

Authors:  D E Griswold; E F Webb; L M Hillegass
Journal:  Inflammation       Date:  1991-08       Impact factor: 4.092

3.  Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response.

Authors:  D E Griswold; E F Webb; J Breton; J R White; P J Marshall; T J Torphy
Journal:  Inflammation       Date:  1993-06       Impact factor: 4.092

4.  Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation.

Authors:  T S Rao; J L Currie; A F Shaffer; P C Isakson
Journal:  Inflammation       Date:  1993-12       Impact factor: 4.092
  4 in total

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