Literature DB >> 7407927

Linkage of adult alpha- and beta-globin genes in X. laevis and gene duplication by tetraploidization.

A J Jeffreys, V Wilson, D Wood, J P Simons, R M Kay, J G Williams.   

Abstract

We have used cloned adult X. laevis alpha- and beta-globin cDNAs to analyze globin genes in X. laevis DNA. We detected alpha 1- and beta 1-globin genes which contain intervening sequences and code for the major adult globins, plus additional diverged alpha 2- and beta 2-globin genes of unknown coding potential. Unlike the case in mammals, the X. laevis alpha 1- and beta 1-globin genes are closely linked and occur in the sequence 5'-alpha 1-9 kb-beta 1-3'. The alpha 2- and beta 2-globin genes are also linked, and analysis of globin genes in X. tropicalis suggests that this duplication of an alpha-beta-globin gene pair in X. laevis is the result of chromosome duplication by tetraploidization. The close linkage of alpha- and beta-globin genes in Xenopus provides evidence that vertebrate alpha- and beta-globin genes evolved by tandem duplication of a single primordial globin gene.

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Year:  1980        PMID： 7407927     DOI： 10.1016/0092-8674(80)90493-6

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  79 in total

1.  Embryonic expression and evolution of duplicated E-protein genes in Xenopus laevis: parallels with ancestral E-protein genes.

Authors:  D H Shain; T Neuman; M X Zuber
Journal:  Genetics       Date:  1997-05       Impact factor: 4.562

2.  Differential flux through the quinate and shikimate pathways. Implications for the channelling hypothesis.

Authors:  H K Lamb; J P van den Hombergh; G H Newton; J D Moore; C F Roberts; A R Hawkins
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

3.  In vivo overproduction of the pentafunctional arom polypeptide in Aspergillus nidulans affects metabolic flux in the quinate pathway.

Authors:  H K Lamb; C R Bagshaw; A R Hawkins
Journal:  Mol Gen Genet       Date:  1991-06

4.  A 78-kilobase region of mouse chromosome 3 contains salivary and pancreatic amylase genes and a pseudogene.

Authors:  K Wiebauer; D L Gumucio; J M Jones; R M Caldwell; H T Hartle; M H Meisler
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

5.  Duplication of the MHC-linked Xenopus complement factor B gene.

Authors:  Y Kato; L Salter-Cid; M F Flajnik; C Namikawa; M Sasaki; M Nonaka
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

6.  Diversity in the origins of sex chromosomes in anurans inferred from comparative mapping of sexual differentiation genes for three species of the Raninae and Xenopodinae.

Authors:  Yoshinobu Uno; Chizuko Nishida; Shin Yoshimoto; Michihiko Ito; Yuki Oshima; Satoshi Yokoyama; Masahisa Nakamura; Yoichi Matsuda
Journal:  Chromosome Res       Date:  2008-10-15       Impact factor: 5.239

7.  Replication and expression of Xenopus laevis globin genes injected into fertilized Xenopus eggs.

Authors:  M M Bendig; J G Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

Review 8.  Gene duplication, genome duplication, and the functional diversification of vertebrate globins.

Authors:  Jay F Storz; Juan C Opazo; Federico G Hoffmann
Journal:  Mol Phylogenet Evol       Date:  2012-07-27       Impact factor: 4.286

9.  The human myoglobin gene: a third dispersed globin locus in the human genome.

Authors:  A J Jeffreys; V Wilson; A Blanchetot; P Weller; A Geurts van Kessel; N Spurr; E Solomon; P Goodfellow
Journal:  Nucleic Acids Res       Date:  1984-04-11       Impact factor: 16.971

10.  Fidelity of transcription of Xenopus laevis globin genes injected into Xenopus laevis oocytes and unfertilized eggs.

Authors:  M M Bendig; J G Williams
Journal:  Mol Cell Biol       Date:  1984-10       Impact factor: 4.272
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