Literature DB >> 7406875

The effect of fluoride on the state of aggregation of adenylate cyclase in rat liver plasma membranes.

B R Martin, J M Stein, E L Kennedy, C A Doberska.   

Abstract

Irradiation inactivation was used to monitor changes in the state of adenylate cyclase in rat liver plasma membranes in the presence of F-.F- caused a decrease in the target size from 328000 to 237000 at 0 degrees C and from 329000 to 219000 at 30 degrees C. Adenylate cyclase was activated by F- at both 0 degrees C and 30 degrees C. The effect of F- was biphasic, activating up to a concentration of 10mM and inhibiting at higher concentrations. If adenylate cyclase weas maximally activated with glucagon and p[NH]ppG ([beta gamma-imido]GTP) all concentrations of F- were inhibitory. The implications of the results with respect to the mechanism of activation of adenylate cyclase are discussed.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7406875      PMCID： PMC1162547          DOI： 10.1042/bj1880137

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Transient complexes. A new structural model for the activation of adenylate cyclase by hormone receptors (guanine nucleotides/irradiation inactivation).

Authors:  B R Martin; J M Stein; E L Kennedy; C A Doberska; J C Metcalfe
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

2.  Effects of glucagon on cyclic AMP and carbohydrate metabolism in livers from diabetic rats.

Authors:  S J Pilkis; J H Exton; R A Johnson; C R Park
Journal:  Biochim Biophys Acta       Date:  1974-03-20

3.  A highly sensitive adenylate cyclase assay.

Authors:  Y Salomon; C Londos; M Rodbell
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

4.  The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: reversibility and dependence on concentration of free hormone.

Authors:  L Birnbaumer; S L Pohl; M Rodbell; F Sundby
Journal:  J Biol Chem       Date:  1972-04-10       Impact factor: 5.157

5.  Membrane enzyme systems. Molecular size determinations by radiation inactivation.

Authors:  G R Kepner; R I Macey
Journal:  Biochim Biophys Acta       Date:  1968-09-17

6.  Changes in the form of Arrhenius plots of the activity of glucagon-stimulated adenylate cyclase and other hamster liver plasma-membrane enzymes occurring on hibernation.

Authors:  M D Houslay; R W Palmer
Journal:  Biochem J       Date:  1978-09-15       Impact factor: 3.857

7.  The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties.

Authors:  S L Pohl; L Birnbaumer; M Rodbell
Journal:  J Biol Chem       Date:  1971-03-25       Impact factor: 5.157

8.  The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it.

Authors:  M D Houslay; J C Metcalfe; G B Warren; T R Hesketh; G A Smith
Journal:  Biochim Biophys Acta       Date:  1976-06-17

9.  A simple enzymic method for the synthesis of adenosine 5'-[alpha-32P]triphosphate on a preparative scale.

Authors:  B R Martin; H P Voorheis
Journal:  Biochem J       Date:  1977-03-01       Impact factor: 3.857
  9 in total
  5 in total

1.  Effect of fluoride on the intestinal epithelial cell brush border membrane.

Authors:  R Rastogi; R K Upreti; A M Kidwai
Journal:  Bull Environ Contam Toxicol       Date:  1987-07       Impact factor: 2.151

2.  Fluoride and lipid peroxidation: a comparative study in different rat tissues.

Authors:  R M Shayiq; H Raza; A M Kidwai
Journal:  Bull Environ Contam Toxicol       Date:  1986-07       Impact factor: 2.151

Review 3.  Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor--cyclase coupling.

Authors:  L E Limbird
Journal:  Biochem J       Date:  1981-04-01       Impact factor: 3.857

4.  Sodium fluoride activation of human lymphocyte adenylate cyclase is reduced in old age.

Authors:  V M Doyle; K O'Malley; J G Kelly
Journal:  Br J Clin Pharmacol       Date:  1982-06       Impact factor: 4.335

5.  Activation of adenylate cyclase in bovine corpus-luteum membranes by human choriogonadotropin, guanine nucleotides and NaF.

Authors:  N B Lydon; J L Young; D A Stansfield
Journal:  Biochem J       Date:  1981-09-15       Impact factor: 3.857
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.