Literature DB >> 7402351

Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75.

M Verhoeyen, R Fang, W M Jou, R Devos, D Huylebroeck, E Saman, W Fiers.   

Abstract

A DNA copy of the gene coding for the influenza A/Aichi/2/68 haemagglutinin protein was cloned in the plasmid pBR322 and the complete nucleotide sequence determined. Comparison of this primary structure and the deduced amino acid sequence with the haemagglutinin gene and protein of strains belonging to the same (H3) subtype and to different subtypes, of both human (H2) and avian (Hav1) origin, documents further at the molecular level the two independent modes of antigenic variation of the virus--drift and shift.

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Year:  1980        PMID： 7402351     DOI： 10.1038/286771a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  87 in total

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7.  Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes.

Authors:  M Krystal; R M Elliott; E W Benz; J F Young; P Palese
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8.  Effect of the addition of oligosaccharides on the biological activities and antigenicity of influenza A/H3N2 virus hemagglutinin.

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9.  Tryptic peptide analysis of outer capsid polypeptides of mammalian reovirus serotypes 1, 2, and 3.

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