Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 15-Hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation.

Literature DB >> 7401944

15-Hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation.

Abstract

Using human platelets isolated from their plasma, we showed that 15-hydroperoxyu-eicosatetraenoic acid (15-HPETE) inhibits platelet aggregation induced either by arachidonic acid or prostaglandin H2 analog. 15-HPETE does not modify platelet prostaglandin and thromboxane formation from exogenous arachidonic acid but does decrease platelet lipoxygenase activity.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 7401944 DOI： 10.1007/bf02534075

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

17 in total

1. Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors: G V BORN
Journal: Nature Date: 1962-06-09 Impact factor: 49.962

2. A new sensitive assay for the measurement of hydroperoxides.

Authors: R L Heath; A L Tappel
Journal: Anal Biochem Date: 1976-11 Impact factor: 3.365

3. Resolution of prostaglandin endoperoxide synthase and thromboxane synthase of human platelets.

Authors: S Hammarström; P Falardeau
Journal: Proc Natl Acad Sci U S A Date: 1977-09 Impact factor: 11.205

4. Aspirin selectively inhibits prostaglandin production in human platelets.

Authors: J B Smith; A L Willis
Journal: Nat New Biol Date: 1971-06-23

5. Study of the two pathways for arachidonate oxygenation in blood platelets.

Authors: C E Dutilh; E Haddeman; G H Jouvenaz; F Ten Hoor; D H Nugteren
Journal: Lipids Date: 1979-02 Impact factor: 1.880

6. The chemical structure of prostaglandin X (prostacyclin).

Authors: N Whittaker; S Bunting; J Salmon; S Moncada; J R Vane; R A Johnson; D R Morton; J H Kinner; R R Gorman; J C McGuire; F F Sun
Journal: Prostaglandins Date: 1976-12

7. A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation.

Authors: S Moncada; R J Gryglewski; S Bunting; J R Vane
Journal: Prostaglandins Date: 1976-11

8. Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides.

Authors: R J Gryglewski; S Bunting; S Moncada; R J Flower; J R Vane
Journal: Prostaglandins Date: 1976-11

9. Preparation and purification of lipid hydroperoxides from arachidonic and gamma-linolenic acids.

Authors: M O Funk; R Isacc; N A Porter
Journal: Lipids Date: 1976-02 Impact factor: 1.880

10. Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation.

Authors: S Moncada; E A Higgs; J R Vane
Journal: Lancet Date: 1977-01-01 Impact factor: 79.321

4 in total

1. Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation.

Authors: C Calzada; E Vericel; M Lagarde
Journal: Biochem J Date: 1997-07-15 Impact factor: 3.857