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Literature DB >> 12538

The chemical structure of prostaglandin X (prostacyclin).

N Whittaker, S Bunting, J Salmon, S Moncada, J R Vane, R A Johnson, D R Morton, J H Kinner, R R Gorman, J C McGuire, F F Sun.

Abstract

The chemical structure of prostaglandin X, the anti-aggregatory substance derived from prostaglandin endoperoxides, is 9-deoxy-6, 6alpha-epoxy-delta5-PGF1alpha. The stable compound formed when prostaglandin X undergoes a chemical transformation in biological systems in 6-keto-PGF1alpha. Prostaglandin X is stabilized in aqueous preparations by raising the pH to 8.5 or higher. The trivial name prostacyclin is proposed for 9-deoxy-6, 9alpha-epoxy-delta5-PGF1alpha.

Entities: Chemical

Mesh：

Substances：

Year: 1976 PMID： 12538 DOI： 10.1016/0090-6980(76)90126-x

Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980

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Cited

88 in total

1. Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin.

Authors: J W Burch; N L Baenziger; N Stanford; P W Majerus
Journal: Proc Natl Acad Sci U S A Date: 1978-10 Impact factor: 11.205

Review 2. Adventures in vascular biology: a tale of two mediators.

Authors: S Moncada
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2006-05-29 Impact factor: 6.237

Review 3. Learning how membrane fatty acids affect cardiovascular integrity.

Authors: William E M Lands
Journal: J Membr Biol Date: 2005-07 Impact factor: 1.843

4. Twenty-four- and 48-hour canine liver preservation by simple hypothermia with prostacyclin.

Authors: M Monden; J G Fortner
Journal: Ann Surg Date: 1982-07 Impact factor: 12.969

5. Stimulation of renin release by 6-oxo-prostaglandin E1 and prostacyclin.

Authors: J C McGiff; E G Spokas; P Y Wong
Journal: Br J Pharmacol Date: 1982-01 Impact factor: 8.739

6. Effects of oestrogen therapy and orchidectomy on coagulation and prostanoid synthesis in patients with prostatic cancer.

Authors: P Henriksson; M Blombäck; G Bratt; O Edhag; A Eriksson; O Vesterqvist
Journal: Med Oncol Tumor Pharmacother Date: 1989

The chemical structure of prostaglandin X (prostacyclin).

1. Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin.

Review 2. Adventures in vascular biology: a tale of two mediators.

Review 3. Learning how membrane fatty acids affect cardiovascular integrity.

4. Twenty-four- and 48-hour canine liver preservation by simple hypothermia with prostacyclin.

5. Stimulation of renin release by 6-oxo-prostaglandin E1 and prostacyclin.

6. Effects of oestrogen therapy and orchidectomy on coagulation and prostanoid synthesis in patients with prostatic cancer.

7. Effects of naproxen on the in vivo synthesis of thromboxane and prostacyclin in man.

8. Effects of nicotine on cardiac prostaglandin and platelet thromboxane synthesis.

9. Prostaglandins and model aspects of thrombosis.

10. Antiinflammatory properties of a hydroperoxide compound, structurally related to acetylsalicylic acid.