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Literature DB >> 740126

A possible mechanism for cholesteryl ester formation during demyelination: lecithin:cholesterol acyltransferase (LCAT) activity in rat brain.

L Amaducci, P Antuono, L Bartolini, G E De Medio, D Inzitari, G Porcellati.

Abstract

Lecithin:cholesterol acyltransferase (LCAT) activity has been examined in the rat by using a brain homogenate preparation as the phospholipid substrate and blood plasma as the enzyme source. LCAT activity was detected on using 60 mul of serum onwards. Successive experiments have also shown that LCAT activity is present in the edematous rat brain tissue homogenate when incubated with inactivated rat plasma as substrate. The results are discussed in relation to cholesteryl ester accumulation in brain during demyelinating diseases.

Entities: Chemical Disease Gene Species

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Year: 1978 PMID： 740126 DOI： 10.1007/bf00965995

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

21 in total

1. THE FORMATION OF PHOSPHOLIPIDS FROM L4C-LABELLED PRECURSORS IN DEVELOPING RAT BRAIN IN VIVO.

Authors: E T PRITCHARD
Journal: J Neurochem Date: 1963-07 Impact factor: 5.372

2. Soluble cerebral proteins in normal and oedematous brain.

Authors: J N CUMINGS
Journal: J Clin Pathol Date: 1961-05 Impact factor: 3.411

3. Lipid chemistry of the brain in demyelinating diseases.

Authors: J N CUMINGS
Journal: Brain Date: 1955 Impact factor: 13.501

4. The cerebral lipids in disseminated sclerosis and in amaurotic family idiocy.

Authors: J N CUMINGS
Journal: Brain Date: 1953 Impact factor: 13.501

5. Enzymes of cholesterol ester metabolism in the brain of mutant mice, quaking and jimpy.

Authors: Y Eto; K Suzuki
Journal: Exp Neurol Date: 1973-10 Impact factor: 5.330

6. Developmental changes of cholesterol ester hydrolases localized in myelin and microsomes of rat brain.

Authors: Y Eto; K Suzuki
Journal: J Neurochem Date: 1973-05 Impact factor: 5.372

7. Cholesterol ester metabolism in rat brain. A cholesterol ester hydrolase specifically localized in the myelin sheath.

Authors: Y Eto; K Suzuki
Journal: J Biol Chem Date: 1973-03-25 Impact factor: 5.157

8. Enzyme activities associated with the demyelinating phase of canine distemper. I. Beta-glucuronidase, acid and neutral proteinases.

Authors: D N McMartin; A Koestner; J F Long
Journal: Acta Neuropathol Date: 1972 Impact factor: 17.088

A possible mechanism for cholesteryl ester formation during demyelination: lecithin:cholesterol acyltransferase (LCAT) activity in rat brain.

1. THE FORMATION OF PHOSPHOLIPIDS FROM L4C-LABELLED PRECURSORS IN DEVELOPING RAT BRAIN IN VIVO.

2. Soluble cerebral proteins in normal and oedematous brain.

3. Lipid chemistry of the brain in demyelinating diseases.

4. The cerebral lipids in disseminated sclerosis and in amaurotic family idiocy.

5. Enzymes of cholesterol ester metabolism in the brain of mutant mice, quaking and jimpy.

6. Developmental changes of cholesterol ester hydrolases localized in myelin and microsomes of rat brain.

7. Cholesterol ester metabolism in rat brain. A cholesterol ester hydrolase specifically localized in the myelin sheath.

8. Enzyme activities associated with the demyelinating phase of canine distemper. I. Beta-glucuronidase, acid and neutral proteinases.

Review 9. Immunochemistry and biochemistry of myelin.

Review 10. Chemical pathology of brain degeneration.

Review 1. Proposed mechanism for lipoprotein remodelling in the brain.

2. Chronic spinal cord changes in a high-fat diet-fed male rat model of thoracic spinal contusion.