Literature DB >> 20470897

Proposed mechanism for lipoprotein remodelling in the brain.

Chunjiang Yu1, Katherine L Youmans, Mary J LaDu.   

Abstract

Lipoprotein remodelling in the periphery has been extensively studied. For example, the processing of nascent apoAI particles to cholesterol-loaded HDL lipoproteins during reverse cholesterol transport involves a series of enzymes, transporters in peripheral tissue, as well as other apolipoproteins and lipoproteins. These extensive modifications and interconversions are well defined. Here, we present the hypothesis that a similar process occurs within the blood brain barrier (BBB) via glia-secreted lipid-poor apoE particles undergoing remodelling to become mature central nervous system (CNS) lipoproteins. We further pose several pressing issues and future directions for the study of lipoproteins in the brain. Published by Elsevier B.V.

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Year:  2010        PMID： 20470897      PMCID： PMC3253707          DOI： 10.1016/j.bbalip.2010.05.001

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  31 in total

Review 1.  Lipoprotein receptors in the nervous system.

Authors:  Joachim Herz; Hans H Bock
Journal:  Annu Rev Biochem       Date:  2001-11-09       Impact factor: 23.643

2.  Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes?

Authors:  Frank W Pfrieger
Journal:  Bioessays       Date:  2003-01       Impact factor: 4.345

Review 3.  New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport.

Authors:  H Bryan Brewer; Silvia Santamarina-Fojo
Journal:  Am J Cardiol       Date:  2003-04-03       Impact factor: 2.778

Review 4.  Cholesterol metabolism in the brain.

Authors:  J M Dietschy; S D Turley
Journal:  Curr Opin Lipidol       Date:  2001-04       Impact factor: 4.776

Review 5.  Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal.

Authors:  John M Dietschy; Stephen D Turley
Journal:  J Lipid Res       Date:  2004-08       Impact factor: 5.922

6.  Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells.

Authors:  John F Oram; Gertrud Wolfbauer; Ashley M Vaughan; Chongren Tang; John J Albers
Journal:  J Biol Chem       Date:  2003-10-14       Impact factor: 5.157

7.  An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.

Authors:  John F Oram; Gertrud Wolfbauer; Chongren Tang; W Sean Davidson; John J Albers
Journal:  J Biol Chem       Date:  2008-02-19       Impact factor: 5.157

8.  A possible mechanism for cholesteryl ester formation during demyelination: lecithin:cholesterol acyltransferase (LCAT) activity in rat brain.

Authors:  L Amaducci; P Antuono; L Bartolini; G E De Medio; D Inzitari; G Porcellati
Journal:  Neurochem Res       Date:  1978-12       Impact factor: 3.996

9.  Regulation of sterol synthesis and of 3-hydroxy-3-methylglutaryl coenzyme A reductase by lipoproteins in glial cells in primary culture.

Authors:  T J Langan; Y Iimori; G White; J J Volpe
Journal:  J Neurosci Res       Date:  1987       Impact factor: 4.164

10.  LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.

Authors:  Veronica Hirsch-Reinshagen; James Donkin; Sophie Stukas; Jennifer Chan; Anna Wilkinson; Jianjia Fan; John S Parks; Jan Albert Kuivenhoven; Dieter Lütjohann; Haydn Pritchard; Cheryl L Wellington
Journal:  J Lipid Res       Date:  2008-12-08       Impact factor: 5.922
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  23 in total

1.  Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift.

Authors:  Mary Jo LaDu; Gregory W Munson; Lisa Jungbauer; Godfrey S Getz; Catherine A Reardon; Leon M Tai; Chunjiang Yu
Journal:  Biochim Biophys Acta       Date:  2011-11-23

Review 2.  ATP-binding cassette transporter A1: from metabolism to neurodegeneration.

Authors:  Radosveta Koldamova; Nicholas F Fitz; Iliya Lefterov
Journal:  Neurobiol Dis       Date:  2014-05-17       Impact factor: 5.996

3.  Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.

Authors:  Lance A Johnson; Reid H J Olsen; Louise S Merkens; Andrea DeBarber; Robert D Steiner; Patrick M Sullivan; Nobuyo Maeda; Jacob Raber
Journal:  Neurobiol Dis       Date:  2014-01-09       Impact factor: 5.996

4.  Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects.

Authors:  Jing Chen; Lucio G Costa; Marina Guizzetti
Journal:  J Pharmacol Exp Ther       Date:  2011-05-31       Impact factor: 4.030

5.  Apolipoproteins in the brain: implications for neurological and psychiatric disorders.

Authors:  David A Elliott; Cyndi Shannon Weickert; Brett Garner
Journal:  Clin Lipidol       Date:  2010-08-01

Review 6.  HDL and cognition in neurodegenerative disorders.

Authors:  David A Hottman; Dustin Chernick; Shaowu Cheng; Zhe Wang; Ling Li
Journal:  Neurobiol Dis       Date:  2014-08-13       Impact factor: 5.996

7.  Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis.

Authors:  Jing Chen; Xiaolu Zhang; Handojo Kusumo; Lucio G Costa; Marina Guizzetti
Journal:  Biochim Biophys Acta       Date:  2012-09-23

8.  Phospholipid transfer protein is expressed in cerebrovascular endothelial cells and involved in high density lipoprotein biogenesis and remodeling at the blood-brain barrier.

Authors:  Anil Paul Chirackal Manavalan; Alexandra Kober; Jari Metso; Ingrid Lang; Tatjana Becker; Karin Hasslitzer; Martina Zandl; Elham Fanaee-Danesh; Jyotsna Brijesh Pippal; Vinay Sachdev; Dagmar Kratky; Jasminka Stefulj; Matti Jauhiainen; Ute Panzenboeck
Journal:  J Biol Chem       Date:  2013-12-25       Impact factor: 5.157

9.  Prenatal Ethanol Exposure Up-Regulates the Cholesterol Transporters ATP-Binding Cassette A1 and G1 and Reduces Cholesterol Levels in the Developing Rat Brain.

Authors:  Chunyan Zhou; Jing Chen; Xiaolu Zhang; Lucio G Costa; Marina Guizzetti
Journal:  Alcohol Alcohol       Date:  2014-07-31       Impact factor: 2.826

10.  Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.

Authors:  Leon M Tai; Kevin P Koster; Jia Luo; Sue H Lee; Yue-Ting Wang; Nicole C Collins; Manel Ben Aissa; Gregory R J Thatcher; Mary Jo LaDu
Journal:  J Biol Chem       Date:  2014-09-12       Impact factor: 5.157
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