Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Multidose studies in the human metabolism of pentobarbitone.

Literature DB >> 7398680

Multidose studies in the human metabolism of pentobarbitone.

Abstract

The metabolism of pentobarbitone has been investigated in two healthy volunteers, and the urinary excretion of unchanged drug, and the products of omega- and (omega-1)-oxidation, quantified for four days after each of three doses to each volunteer. The rates of excretion are discussed in terms which include enzyme induction effects.

Entities: Chemical Species

Mesh：

Substances：
Pentobarbital

Year: 1980 PMID： 7398680 DOI： 10.1007/BF03189449

Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.441

18 in total

1. The interaction of barbiturates with serum albumin and its possible relation to their disposition and pharmacological actions.

Authors: L R GOLDBAUM; P K SMITH
Journal: J Pharmacol Exp Ther Date: 1954-06 Impact factor: 4.030

2. Ethyl (3-hydroxy-1-methylbutyl) barbituric acids as metabolites of pentobarbital.

Authors: E W MAYNERT; J M DAWSON
Journal: J Biol Chem Date: 1952-03 Impact factor: 5.157

3. Metabolism of quinalbarbitone.

Authors: J N Gilbert; W L Hetherington; J W Powell; W B Whalley
Journal: J Pharm Pharmacol Date: 1975-05 Impact factor: 3.765

4. N-Hydroxyamylobarbitone--a metabolite of amylobarbitone?

Authors: J N Gilbert; P T Nelmes; J W Powell; S Murray
Journal: J Pharm Pharmacol Date: 1978-09 Impact factor: 3.765

5. Pharmacokinetics and distribution properties of pentobarbital in humans following oral and intravenous administration.

Authors: M Ehrnebo
Journal: J Pharm Sci Date: 1974-07 Impact factor: 3.534

6. Effect of physicochemical and pharmacokinetic properties of barbiturates on the induction of drug metabolism.

Authors: O Pelkonen; N T Kärki
Journal: Chem Biol Interact Date: 1973-08 Impact factor: 5.192

7. Synthesis and absolute stereochemistry of 5-alkyl-5-(3'-hydroxy-1'-methylbutyl)barbituric acid and 5-alkyl-5-(3'-hydroxy-1'-methylbutyl)-2-thiobarbituric acids.

Authors: F I Carroll; G N Mitchell
Journal: J Med Chem Date: 1975-01 Impact factor: 7.446

Multidose studies in the human metabolism of pentobarbitone.

1. The interaction of barbiturates with serum albumin and its possible relation to their disposition and pharmacological actions.

2. Ethyl (3-hydroxy-1-methylbutyl) barbituric acids as metabolites of pentobarbital.

3. Metabolism of quinalbarbitone.

4. N-Hydroxyamylobarbitone--a metabolite of amylobarbitone?

5. Pharmacokinetics and distribution properties of pentobarbital in humans following oral and intravenous administration.

6. Effect of physicochemical and pharmacokinetic properties of barbiturates on the induction of drug metabolism.

7. Synthesis and absolute stereochemistry of 5-alkyl-5-(3'-hydroxy-1'-methylbutyl)barbituric acid and 5-alkyl-5-(3'-hydroxy-1'-methylbutyl)-2-thiobarbituric acids.

8. Distinctive patterns of amobarbital metabolites.

9. Hydantoin ring glucuronidation: characterization of a new metabolite of 5,5-diphenylhydantoin in man and the rat.

10. Pentobarbital elimination in patients with poor renal function.

Review 1. Pharmacodynamics and pharmacokinetics of thiopental.

2. Time-dependent pharmacokinetics of high dose thiopental infusion in intensive care patients.

3. Identification of the diastereomers of pentobarbital N-glucosides excreted in human urine.

Review 4. Clinical pharmacokinetic considerations in the treatment of increased intracranial pressure.