Literature DB >> 7397447

Blockage by yohimbine of prazosin-resistant pressor effects of adrenaline in the pithed rat.

N A Flavahan, J C McGrath.   

Abstract

In the pithed rat, following beta-adrenoceptor blockade, the pressor effect of adrenaline can be blocked by phentolamine or by prazosin plus yohimbine but not by prazosin or yohimbine given alone. It is concluded that adrenaline produces its pressor effect by acting on two sets of post-junctional alpha-adrenoceptors, each of which is sensitive to phentolamine, one of which is sensitive to prazosin but resistant to yohimbine and the other of which is sensitive to yohimbine but resistant to prazosin.

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Year:  1980        PMID： 7397447      PMCID： PMC2044272          DOI： 10.1111/j.1476-5381.1980.tb07021.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.

Authors:  K Starke; E Borowski; T Endo
Journal:  Eur J Pharmacol       Date:  1975-12       Impact factor: 4.432

2.  A comparison of pre- and postsynaptic effects of alpha-adrenolytic drugs in the pulmonary artery of the rabbit.

Authors:  E Borowski; K Starke; H Ehrl; T Endo
Journal:  Neuroscience       Date:  1977       Impact factor: 3.590

3.  An analysis of some factors influencing alpha-adrenoceptor feed-back at the sympathetic junction in the rat heart.

Authors:  J R Docherty; J C McGrath
Journal:  Br J Pharmacol       Date:  1979-05       Impact factor: 8.739

4.  A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.

Authors:  J S Gillespie; A Maclaren; D Pollock
Journal:  Br J Pharmacol       Date:  1970-10       Impact factor: 8.739

5.  Evidence for two distinct types of postsynaptic alpha-adrenoceptor in vascular smooth muscle in vivo.

Authors:  G M Drew; S B Whiting
Journal:  Br J Pharmacol       Date:  1979-10       Impact factor: 8.739
  5 in total
  11 in total

1.  Regional variation in the alpha-adrenergic receptors in the canine resistance vessels.

Authors:  P T Horn; J D Kohli; J J Listinsky; L I Goldberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-02       Impact factor: 3.000

2.  Pharmacological analysis of postjunctional alpha-adrenoceptors mediating contractions to (-)-noradrenaline in the rabbit isolated lateral saphenous vein can be explained by interacting responses to simultaneous activation of alpha 1- and alpha 2-adrenoceptors.

Authors:  C J Daly; J C McGrath; V G Wilson
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

3.  Proceedings of the British Pharmacological Society. 10th-12th September, 1980. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1981-03       Impact factor: 8.739

4.  A comparison of the actions of noradrenaline and UK-14,304 in the longitudinal smooth muscle of the rat isolated portal vein--no evidence for a population of post-junctional alpha 2-adrenoceptors.

Authors:  O A Downing; W Stein; K A Wilson; V G Wilson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-09       Impact factor: 3.000

5.  Organic and inorganic calcium antagonists reduce vasoconstriction in vivo mediated by postsynaptic alpha 2-adrenoceptors.

Authors:  J C Van Meel; A de Jonge; H O Kalkman; B Wilffert; P B Timmermans; P A van Zwieten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-07       Impact factor: 3.000

6.  Acute dilation to alpha(2)-adrenoceptor antagonists uncovers dual constriction and dilation mediated by arterial alpha(2)-adrenoceptors.

Authors:  P A Crassous; S Flavahan; N A Flavahan
Journal:  Br J Pharmacol       Date:  2009-09-28       Impact factor: 8.739

7.  Effects of reduced calcium ion concentration and of diltiazem on vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation in rat isolated tail artery.

Authors:  I C Medgett; M A Rajanayagam
Journal:  Br J Pharmacol       Date:  1984-12       Impact factor: 8.739

8.  An examination of the postjunctional alpha-adrenoceptor subtypes for (-)-noradrenaline in several isolated blood vessels from the rabbit.

Authors:  C J Daly; J C McGrath; V G Wilson
Journal:  Br J Pharmacol       Date:  1988-10       Impact factor: 8.739

9.  Analysis of the alpha-adrenoceptor-mediated, and other, components in the sympathetic vasopressor responses of the pithed rat.

Authors:  N A Flavahan; T L Grant; J Greig; J C McGrath
Journal:  Br J Pharmacol       Date:  1985-09       Impact factor: 8.739

10.  Postsynaptic alpha 1- and alpha 2-adrenoceptors in the vascular system of the herring gull, Larus argentatus.

Authors:  L E Hermansson; P Johansson
Journal:  Br J Pharmacol       Date:  1986-11       Impact factor: 8.739
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