Literature DB >> 7397133

Linear relation between rate and thermodynamic force in enzyme-catalyzed reactions.

R Van der Meer, H V Westeroff, K Van Dam.   

Abstract

Starting from enzyme kinetics, it is shown that generally a linear rather than a proportional relationship exists between rate and free energy changes in biochemical processes. In the derivation the boundary condition of constant substrate plus product is used, which is appropriate for many cellular systems. An example is the ADP plus ATP concentration is mitochondrial oxidative phosphorylation, as is illustrated experimentally.

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Year:  1980        PMID: 7397133     DOI: 10.1016/0005-2728(80)90179-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  19 in total

1.  An investigation of the relationships between rate and driving force in simple uncatalysed and enzyme-catalysed reactions with applications of the findings to chemiosmotic reactions.

Authors:  C D Stoner
Journal:  Biochem J       Date:  1992-04-15       Impact factor: 3.857

2.  What process is glycolytic stoichiometry optimal for?

Authors:  Alicia Esteban del Valle; J Carlos Aledo
Journal:  J Mol Evol       Date:  2006-03-17       Impact factor: 2.395

3.  Systems biology towards life in silico: mathematics of the control of living cells.

Authors:  Hans V Westerhoff; Alexey Kolodkin; Riaan Conradie; Stephen J Wilkinson; Frank J Bruggeman; Klaas Krab; Jan H van Schuppen; Hanna Hardin; Barbara M Bakker; Martijn J Moné; Katja N Rybakova; Marco Eijken; Hans J P van Leeuwen; Jacky L Snoep
Journal:  J Math Biol       Date:  2008-02-16       Impact factor: 2.259

4.  Linear nonequilibrium thermodynamics describes the dynamics of an autocatalytic system.

Authors:  S Cortassa; M A Aon; H V Westerhoff
Journal:  Biophys J       Date:  1991-10       Impact factor: 4.033

5.  Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/myofibril system in muscle.

Authors:  G J Kemp; D N Manners; J F Clark; M E Bastin; G K Radda
Journal:  Mol Cell Biochem       Date:  1998-07       Impact factor: 3.396

6.  Metabolic control analysis of biochemical pathways based on a thermokinetic description of reaction rates.

Authors:  J Nielsen
Journal:  Biochem J       Date:  1997-01-01       Impact factor: 3.857

7.  Thermodynamic control of electron flux through mitochondrial cytochrome bc1 complex.

Authors:  G C Brown; M D Brand
Journal:  Biochem J       Date:  1985-01-15       Impact factor: 3.857

Review 8.  Regulation of respiration and ATP synthesis in higher organisms: hypothesis.

Authors:  B Kadenbach
Journal:  J Bioenerg Biomembr       Date:  1986-02       Impact factor: 2.945

9.  Thermodynamics of the control of metabolism.

Authors:  H V Westerhoff; P J Plomp; A K Groen; R J Wanders
Journal:  Cell Biophys       Date:  1987-12

10.  Reversible uncoupling of oxidative phosphorylation at low oxygen tension.

Authors:  R S Kramer; R D Pearlstein
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

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