Literature DB >> 7396838

Development of NADPH-producing pathways in rat heart.

A Andrés, J Satrústegui, A Machado.   

Abstract

The behaviours of the principal NADPH-producing enzymes (glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, cytoplasmic and mitochondrial 'malic' enzyme and NAPD+-dependent isocitrate dehydrogenase) were studied during the development of rat heart and compared with those in brain and liver. 1. The enzymes belonging to the pentose phosphate pathway exhibit lower activities in heart than in other tissues throughout development. 2. The pattern of induction of heart cytoplasmic and mitochondrial 'malic' enzymes does not parallel that found in liver. Heart mitochondrial enzyme is slowly induced from birth onwards. 3. NADP+-dependent isocitrate dehydrogenase has similar activities in all tissues in 18-day foetuses. 4. Heart mitochondrial NADP+-dependent isocitrate dehydrogenase is greatly induced in the adult, where it attains a 10-fold higher activity than in liver. 5. The physiological functions of mitochondrial 'malic' enzyme and NADP+-dependent isocitrate dehydrogenase are discussed.

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Year:  1980        PMID： 7396838      PMCID： PMC1161716          DOI： 10.1042/bj1860799

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

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Authors:  J B Clark; W J Nicklas
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Authors:  G W Plaut; T Aogaichi
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Authors:  R G Vernon; D G Walker
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4.  Intracellular location and genetic control of isozymes of NADP-dependent isocitrate dehydrogenase and malate dehydrogenase.

Authors:  N S Henderson
Journal:  Ann N Y Acad Sci       Date:  1968-06-14       Impact factor: 5.691

5.  Significance of substrate inhibition of dehydrogenases.

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6.  Diphosphopyridine nucleotide specific isocitric dehydrogenase of mammalian mitochondria. I. On the roles of pyridine nucleotide transhydrogenase and the isocitric dehydrogenases in the respiration of mitochondria of normal and neoplastic tissues.

Authors:  A M Stein; J H Stein; S K Kirkman
Journal:  Biochemistry       Date:  1967-05       Impact factor: 3.162

7.  Mitochondrial malic enzyme: the source of reduced nicotinamide adenine dinucleotide phosphate for steroid hydroxylation in bovine adrenal cortex mitochondria.

Authors:  E R Simpson; R W Estabrook
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8.  Apparent unbalance between the activities of 6-phosphogluconate and glucose-6-phosphate dehydrogenases in rat liver.

Authors:  M Sapag-Hagar; R Lagunas; A Sols
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Journal:  Biochem J       Date:  1968-01       Impact factor: 3.857

10.  Immunochemical studies with soluble and mitochondrial pyruvate carboxylase activities from rat tissues.

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