Literature DB >> 7242774

Age-related quantitative changes in enzyme activities of rat brain.

J Vitorica, A Andrés, J Satrústegui, A Machado.   

Abstract

The patterns of brain enzymes linked to energy metabolism have been determined in rats aged between 3 and 21 months and compared to those of the developing brain as an estimate of the senescent energy capacity of this organ. During aging, pyruvate kinase increases, pointing towards an enhancement of the glucose-dependence of this organ. However, NAD-isocitrate dehydrogenase declines, suggesting a reduction of Krebs cycle activity in the aged rat brain. An increase in cytoplasmic NAD-malate dehydrogenase found during aging could provide an alternative mechanism of NAD recovery.

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Year:  1981        PMID： 7242774     DOI： 10.1007/bf00964829

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  31 in total

1.  Preparation and properties of mitochondria derived from synaptosomes.

Authors:  J C Lai; J B Clark
Journal:  Biochem J       Date:  1976-02-15       Impact factor: 3.857

2.  Enzymes in intracellular organelles of adult and developing rat brain.

Authors:  P C MacDonnell; O Greengard
Journal:  Arch Biochem Biophys       Date:  1974-08       Impact factor: 4.013

3.  Alterations in lactate dehydrogenase of the brain, heart, skeletal muscle, and liver of rats of various ages.

Authors:  S N Singh; M S Kanungo
Journal:  J Biol Chem       Date:  1968-09-10       Impact factor: 5.157

4.  Mitochondrial malic enzyme: the source of reduced nicotinamide adenine dinucleotide phosphate for steroid hydroxylation in bovine adrenal cortex mitochondria.

Authors:  E R Simpson; R W Estabrook
Journal:  Arch Biochem Biophys       Date:  1969-01       Impact factor: 4.013

5.  Induction and properties of pyruvate kinase of the cerebral hemisphere of rats of various ages.

Authors:  G B Chainy; M S Kanungo
Journal:  J Neurochem       Date:  1978-02       Impact factor: 5.372

6.  Influenza of age on chromatin transcription in murine tissues using a heterologous and an homologous RNA polymerase.

Authors:  B T Hill
Journal:  Gerontology       Date:  1976       Impact factor: 5.140

7.  Effect of aging on brain respiration and carbohydrate metabolism of CBF1 mice.

Authors:  M S Parmacek; J H Fox; W H Harrison; D C Garron; D Swenie
Journal:  Gerontology       Date:  1979       Impact factor: 5.140

8.  The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic data.

Authors:  J E Cremer; D F Heath
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

9.  Comparison between developmental and senescent changes in enzyme activities linked to energy metabolism in rat heart.

Authors:  J Vitorica; J Cano; J Satrústegui; A Machado
Journal:  Mech Ageing Dev       Date:  1981-06       Impact factor: 5.432

10.  Leucine and D-3-hydroxybutyrate as lipid precursors in developing rat spinal cord and liver.

Authors:  R B Ramsey
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857
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  9 in total

1.  Mitochondrial enzymes related to glutamate and GABA metabolism in the hippocampus of young and aged rats: a quantitative histochemical study.

Authors:  P Kugler; G Baier
Journal:  Neurochem Res       Date:  1992-02       Impact factor: 3.996

2.  Quantitative succinate dehydrogenase histochemistry in the hippocampus of aged rats.

Authors:  P Kugler; S Vogel; M Gehm
Journal:  Histochemistry       Date:  1988

3.  Local cerebral glucose utilization in the hippocampus of old rats.

Authors:  W Tack; A Wree; A Schleicher
Journal:  Histochemistry       Date:  1989

4.  Age-related changes in the glutamate metabolism of cerebral cortical slices from rats.

Authors:  H Matsumoto; S Kikuchi; M Ito
Journal:  Neurochem Res       Date:  1982-06       Impact factor: 3.996

5.  Age-related changes of glucose metabolism in rat cerebral cortex with reference to glucose-derived amino acids.

Authors:  H Matsumoto; M Ito; S Kikuchi; M Edamura
Journal:  Neurochem Res       Date:  1985-12       Impact factor: 3.996

6.  Local cerebral glucose utilization in the brain of old, learning impaired rats.

Authors:  A Wree; C Kaever; B Birgel; A Schleicher; E Horvath; K Zilles
Journal:  Histochemistry       Date:  1991

7.  alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice.

Authors:  Sang-Kyu Park; Grier P Page; Kyoungmi Kim; David B Allison; Mohsen Meydani; Richard Weindruch; Tomas A Prolla
Journal:  J Nutr       Date:  2008-06       Impact factor: 4.798

8.  The subunit proportions and kinetic properties of 6-phosphofructo-1-kinase isozymes from rat heart atria and ventricle progressively change during aging.

Authors:  Y Mhaskar; G A Dunaway
Journal:  Mol Cell Biochem       Date:  1991-09-18       Impact factor: 3.396

Review 9.  Mitochondrial dysfunction and oxidative stress in aging and cancer.

Authors:  Anna V Kudryavtseva; George S Krasnov; Alexey A Dmitriev; Boris Y Alekseev; Olga L Kardymon; Asiya F Sadritdinova; Maria S Fedorova; Anatoly V Pokrovsky; Nataliya V Melnikova; Andrey D Kaprin; Alexey A Moskalev; Anastasiya V Snezhkina
Journal:  Oncotarget       Date:  2016-07-19
  9 in total

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