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Literature DB >> 7396714

Skin irritant effects of esters of phorbol and related polyols.

Abstract

The skin irritant potencies of several naturally occurring and semi-synthetic polyfunctional esters based on the tigliane hydrocarbon skeleton were studied using a mouse ear irritancy assay. The compounds used were esters of 12-deoxyphorbol, 12-deoxy-16-hydroxyphorbol, and phorbol. Observations were also made on the time interval between application of these compounds in acetone solution to the mouse ear, and the attainment of maximum response. Structure/activity relationships are discussed and compared with previous observations on the skin irritant potencies of esters based on the closely related daphnane hydrocarbon skeleton. The possible nature of the site of action in the target membrane is also discussed.

Entities: Chemical Species

Mesh：

Substances：

Year: 1980 PMID： 7396714 DOI： 10.1007/bf00278035

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

14 in total

1. Antileukemic principles isolated from euphorbiaceae plants.

Authors: S M Kupchan; I Uchida; A R Branfman; R G Dailey; B Y Fei
Journal: Science Date: 1976-02-13 Impact factor: 47.728

2. Candletoxins A and B, 2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, from the irritant latex of Euphoria poisonii Pax.

Authors: R J Schmidt; F J Evans
Journal: Experientia Date: 1977-09-15

3. The succulent Euphorbias of Nigeria. II. aliphatic diterpene esters of the latices of E. poisonii Pax. and E. unispina N.E. Br.

Authors: R J Schmidt; F J Evans
Journal: Lloydia Date: 1977 May-Jun

Skin irritant effects of esters of phorbol and related polyols.

1. Antileukemic principles isolated from euphorbiaceae plants.

2. Candletoxins A and B, 2 new aromatic esters of 12-deoxy-16-hydroxy-phorbol, from the irritant latex of Euphoria poisonii Pax.

3. The succulent Euphorbias of Nigeria. II. aliphatic diterpene esters of the latices of E. poisonii Pax. and E. unispina N.E. Br.

4. [On the active substances in croton oil. 6. Inflammation tests on the mouse ear].

5. The inhibition of croton oil-promoted mouse skin tumorigenesis by steroid hormones.

6. Hydrophobic free energy, micelle formation and the association of proteins with amphiphiles.

7. The tigliane, daphnane and ingenane diterpenes, their chemistry, distribution and biological activities. A review.

8. Nonspecific inhibition of DNA repair by promoting and nonpromoting phorbol esters.

9. Investigations into the skin-irritant properties of resiniferonol ortho esters.

10. The fluid mosaic model of the structure of cell membranes.

1. The structural requirements for phorbol esters to enhance noradrenaline and dopamine release from rat brain cortex.

2. Structural correlations of phorbol-ester-induced stimulation of PGE2 production by human rheumatoid synovial cells.

3. Vascular changes in rabbit skin induced by proinflammatory phorbol and 12-deoxyphorbol esters.

4. Antinociceptive and Smooth Muscle Relaxant Activity of Croton tiglium L Seed: An In-vitro and In-vivo Study.