Literature DB >> 7393963

The effect of halothane on mice selectively bred for differential sensitivity to alcohol.

R Baker, C Melchior, R Deitrich.   

Abstract

We have investigated the response of mice to halothane that have been selectively bred for either sensitivity (long sleep, LS) or resistance (short sleep, SS) to the anesthetic effects of ethanol. While large differences in the response of the animals to ethanol were observed in sleep time, blood anesthetic concentration at time of awakening, and body temperature, the SS and LS lines did not differ in their response to halothane. We conclude that the mechanism of action of ethanol and halothane differ in a significant way from each other.

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Year:  1980        PMID： 7393963     DOI： 10.1016/0091-3057(80)90150-1

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  7 in total

Review 1.  Selected mouse lines, alcohol and behavior.

Authors:  T J Phillips; D J Feller; J C Crabbe
Journal:  Experientia       Date:  1989-09-15

2.  A stomatin and a degenerin interact to control anesthetic sensitivity in Caenorhabditis elegans.

Authors:  S Rajaram; T L Spangler; M M Sedensky; P G Morgan
Journal:  Genetics       Date:  1999-12       Impact factor: 4.562

Review 3.  Reinterpretation of the literature indicates differential sensitivities of long-sleep and short-sleep mice are not specific to alcohol.

Authors:  T D McIntyre; H P Alpern
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

4.  Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction.

Authors:  Alessandro Gozzi; Federica Agosta; Maurizio Massi; Roberto Ciccocioppo; Angelo Bifone
Journal:  Neuroimage       Date:  2012-12-20       Impact factor: 6.556

5.  Differential effects of long-chain alcohols in long- and short-sleep mice.

Authors:  T C Howerton; M F O'Connor; A C Collins
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

Review 6.  Selective breeding for initial sensitivity to ethanol.

Authors:  R A Deitrich
Journal:  Behav Genet       Date:  1993-03       Impact factor: 2.805

7.  Quantitative trait loci controlling halothane sensitivity in Caenorhabditis elegans.

Authors:  B van Swinderen; D R Shook; R H Ebert; V A Cherkasova; T E Johnson; R J Shmookler Reis; C M Crowder
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205
  7 in total

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