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Literature DB >> 8512530

Selective breeding for initial sensitivity to ethanol.

Abstract

Selective breeding for initial sensitivity to ethanol has been carried out by a number of investigators in order to investigate the mechanisms by which ethanol brings about a myriad of effects on the mammalian central nervous system. In addition the availability of these selectively bred animals provides clues to the causes of the genetic predisposition of humans to alcoholism. Eventually it is envisioned that the synteny between the mouse and human genomes will allow identification of specific genes responsible for acute effects of ethanol in both species as well as clues as to how alcoholism in humans can be better identified, prevented, and treated.

Entities: Chemical Species

Mesh：

Substances：
Genetic Markers

Year: 1993 PMID： 8512530 DOI： 10.1007/BF01067420

Source DB: PubMed Journal: Behav Genet ISSN： 0001-8244 Impact factor: 2.805

53 in total

1. Further characterization of LSxSS recombinant inbred strains of mice: activating and hypothermic effects of ethanol.

Authors: V G Erwin; B C Jones; R Radcliffe
Journal: Alcohol Clin Exp Res Date: 1990-04 Impact factor: 3.455

2. Responses to cholinergic agonists of rats selectively bred for differential sensitivity to ethanol.

Authors: C M de Fiebre; E Romm; J T Collins; L J Draski; R A Deitrich; A C Collins
Journal: Alcohol Clin Exp Res Date: 1991-03 Impact factor: 3.455

3. A comparison of sensitivity to oxotremorine and muscarinic receptors in LS and SS mice.

Authors: A C Collins; S M Campbell; E Romm; M J Marks
Journal: Alcohol Clin Exp Res Date: 1990-08 Impact factor: 3.455

4. Differential regulation of anterior pituitary corticotrope function is observed in vivo but not in vitro in two lines of ethanol-sensitive mice.

Authors: G S Wand
Journal: Alcohol Clin Exp Res Date: 1990-02 Impact factor: 3.455

5. Variation of nicotinic binding sites among inbred strains.

Authors: M J Marks; E Romm; S M Campbell; A C Collins
Journal: Pharmacol Biochem Behav Date: 1989-07 Impact factor: 3.533

6. Hormonal tolerance to ethanol is associated with decreased expression of the GTP-binding protein, Gs alpha, and adenylyl cyclase activity in ethanol-treated LS mice.

Authors: G S Wand; M A Levine
Journal: Alcohol Clin Exp Res Date: 1991-08 Impact factor: 3.455

7. Physical properties and lipid composition of brain membranes from ethanol tolerant-dependent mice.

Authors: R A Harris; D M Baxter; M A Mitchell; R J Hitzemann
Journal: Mol Pharmacol Date: 1984-05 Impact factor: 4.436

8. Effects of ethanol and calcium on lipid order of membranes from mice selected for genetic differences in ethanol intoxication.

Authors: R A Harris; L M Zaccaro; S McQuilkin; A McClard
Journal: Alcohol Date: 1988 May-Jun Impact factor: 2.405

6. Restraint stress and exogenous corticosterone differentially alter sensitivity to the sedative-hypnotic effects of ethanol in inbred long-sleep and inbred short-sleep mice.

Authors: Clarissa Carlin Parker; Heather Ponicsan; Robert Leon Spencer; Andrew Holmes; Thomas Eugene Johnson
Journal: Alcohol Date: 2008-09 Impact factor: 2.405

6 in total

Selective breeding for initial sensitivity to ethanol.

1. Further characterization of LSxSS recombinant inbred strains of mice: activating and hypothermic effects of ethanol.

2. Responses to cholinergic agonists of rats selectively bred for differential sensitivity to ethanol.

3. A comparison of sensitivity to oxotremorine and muscarinic receptors in LS and SS mice.

4. Differential regulation of anterior pituitary corticotrope function is observed in vivo but not in vitro in two lines of ethanol-sensitive mice.

5. Variation of nicotinic binding sites among inbred strains.

6. Hormonal tolerance to ethanol is associated with decreased expression of the GTP-binding protein, Gs alpha, and adenylyl cyclase activity in ethanol-treated LS mice.

7. Physical properties and lipid composition of brain membranes from ethanol tolerant-dependent mice.

8. Effects of ethanol and calcium on lipid order of membranes from mice selected for genetic differences in ethanol intoxication.

9. Investigations of the role of protein kinase C in the acute sedative effects of ethanol.

10. Central muscarinic cholinergic influences on ethanol sensitivity in long-sleep and short-sleep mice.

1. Ethanol tolerance and withdrawal severity in high drinking in the dark selectively bred mice.

Review 2. Human and laboratory rodent low response to alcohol: is better consilience possible?

3. Acetate-dependent mechanisms of inborn tolerance to ethanol.

4. Quantitative trait loci for ethanol sensitivity in the LS x SS recombinant inbred strains: interval mapping.

5. Synaptic GABAergic and glutamatergic mechanisms underlying alcohol sensitivity in mouse hippocampal neurons.

6. Restraint stress and exogenous corticosterone differentially alter sensitivity to the sedative-hypnotic effects of ethanol in inbred long-sleep and inbred short-sleep mice.