Literature DB >> 7389752

Variation in human metabolism of S-carboxymethylcysteine.

R H Waring.   

Abstract

The metabolism of an oral dose of S-carboxymethylcysteine (SCMC) has been studied in man; the principal urinary component after 24 h was the unchanged compound (29.4-83.7%, 20 subjects). Markers variation was found between individuals; SCMC sulphoxide, S-methylcysteine, N-acetyl-S-carboxymethylcysteine, N-acetyl-S-methylcysteine with the corresponding sulphoxides and dicarboxymethylsulphide were also found as metabolites.

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Year:  1980        PMID： 7389752     DOI： 10.1007/BF03189444

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  10 in total

1.  THE METABOLISM OF S-METHYL-L-CYSTEINE IN THE RAT.

Authors:  E A BARNSLEY
Journal:  Biochim Biophys Acta       Date:  1964-07-15

2.  Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids.

Authors:  R H KNIGHT; L YOUNG
Journal:  Biochem J       Date:  1958-09       Impact factor: 3.857

3.  The metabolism of S-carboxyalkylcysteines in man.

Authors:  K M Rogers; E A Barnsley
Journal:  Xenobiotica       Date:  1977-07       Impact factor: 1.908

4.  The acetylation of S-alkylcysteines by the rat.

Authors:  E A Barnsley; N A Eskin; S P James; R H Waring
Journal:  Biochem Pharmacol       Date:  1969-10       Impact factor: 5.858

5.  Formation of mercapturic acids. 5. Metabolism of some halogenoparaffins and nitroparaffins.

Authors:  H G Bray; J C Caygill; S P James; P B Wood
Journal:  Biochem J       Date:  1964-01       Impact factor: 3.857

6.  Biochemical studies of toxic agents. 15. The biosynthesis of ethylmercapturic acid sulphoxide.

Authors:  E A Barnsley; A E Thomson; L Young
Journal:  Biochem J       Date:  1964-03       Impact factor: 3.857

7.  The metabolism of S-carboxymethylcysteine in rodents, marmosets and humans.

Authors:  R H Waring
Journal:  Xenobiotica       Date:  1978-05       Impact factor: 1.908

8.  Separation of mercapturic acids and related compounds by gas chromatography and a method for the determination of hippuric acid.

Authors:  S P James; R H Waring; D A White
Journal:  J Chromatogr       Date:  1967-01

9.  Excretion and biotransformation of carboxymethyl-cysteine in rat, dog, monkey and man.

Authors:  L B Turnbull; L Teng; J M Kinzie; J E Pitts; F M Pinchbeck; R B Bruce
Journal:  Xenobiotica       Date:  1978-10       Impact factor: 1.908

10.  The metabolism of S-methyl-L-cysteine.

Authors:  N M Sklan; E A Barnsley
Journal:  Biochem J       Date:  1968-03       Impact factor: 3.857
  10 in total
  4 in total

Review 1.  Molecular basis of polymorphic drug metabolism.

Authors:  A K Daly
Journal:  J Mol Med (Berl)       Date:  1995-11       Impact factor: 4.599

2.  Evaluation of proposed sulphoxidation pathways of carbocysteine in man by HPLC quantification.

Authors:  J Brockmöller; B Staffeldt; I Roots
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

3.  Genetic aspects of the polymodally distributed sulphoxidation of S-carboxymethyl-L-cysteine in man.

Authors:  S C Mitchell; R H Waring; C S Haley; J R Idle; R L Smith
Journal:  Br J Clin Pharmacol       Date:  1984-10       Impact factor: 4.335

4.  An investigation of the metabolism of S-carboxymethyl-L-cysteine in man using a novel HPLC-ECD method.

Authors:  E F Karim; J S Millership; D J Temple; A D Woolfson
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Oct-Dec       Impact factor: 2.441
  4 in total

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