Literature DB >> 3243319

An investigation of the metabolism of S-carboxymethyl-L-cysteine in man using a novel HPLC-ECD method.

E F Karim1, J S Millership, D J Temple, A D Woolfson.   

Abstract

The metabolism of an oral dose of S-carboxymethyl-L-cysteine (SCMC) in man has been studied; the quantitative determination of SCMC, S-methyl-L-cysteine (SMC) and their sulphoxide metabolites (SCMCO and SMCO), in urine, was carried out using high performance liquid chromatography (HPLC) with electrochemical detection (ECD); the possibility of stereospecific sulphoxidation was investigated.

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Year:  1988        PMID： 3243319     DOI： 10.1007/BF03190087

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  11 in total

1.  (+)-(S-methyl-L-cysteine S-oxide) in cabbage.

Authors:  R L SYNGE; J C WOOD
Journal:  Biochem J       Date:  1956-10       Impact factor: 3.857

2.  A simple method for the approximate determination of S-methylcysteine sulphoxide (kale anaemia factor).

Authors:  N A Matheson; A W Moir
Journal:  J Sci Food Agric       Date:  1976-10       Impact factor: 3.638

3.  The metabolism of S-carboxyalkylcysteines in man.

Authors:  K M Rogers; E A Barnsley
Journal:  Xenobiotica       Date:  1977-07       Impact factor: 1.908

4.  Formation of mercapturic acids. 5. Metabolism of some halogenoparaffins and nitroparaffins.

Authors:  H G Bray; J C Caygill; S P James; P B Wood
Journal:  Biochem J       Date:  1964-01       Impact factor: 3.857

5.  Genetically determined impaired drug sulphoxidation.

Authors:  R H Waring; S C Mitchell; J R Idle; R L Smith
Journal:  Lancet       Date:  1981-04-04       Impact factor: 79.321

6.  Polymorphic sulphoxidation of S-carboxymethyl-L-cysteine in man.

Authors:  R H Waring; S C Mitchell; R R Shah; J R Idle; R L Smith
Journal:  Biochem Pharmacol       Date:  1982-10-01       Impact factor: 5.858

7.  The metabolism of S-carboxymethylcysteine in rodents, marmosets and humans.

Authors:  R H Waring
Journal:  Xenobiotica       Date:  1978-05       Impact factor: 1.908

8.  Excretion and biotransformation of carboxymethyl-cysteine in rat, dog, monkey and man.

Authors:  L B Turnbull; L Teng; J M Kinzie; J E Pitts; F M Pinchbeck; R B Bruce
Journal:  Xenobiotica       Date:  1978-10       Impact factor: 1.908

9.  The metabolism and elimination of S-carboxymethyl-L-cysteine in man.

Authors:  R H Waring; S C Mitchell
Journal:  Drug Metab Dispos       Date:  1982 Jan-Feb       Impact factor: 3.922

10.  Variation in human metabolism of S-carboxymethylcysteine.

Authors:  R H Waring
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1980       Impact factor: 2.441
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