Literature DB >> 7388815

Inability of Chinese hamster ovary cells to excise O6-alkylguanine.

R Goth-Goldstein.   

Abstract

The capacity of Chinese hamster ovary cells for excising alkylated bases from their DNA was investigated. Cells were treated with N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea, and the amounts of 3-alkyladenine, 7-alkylguanine, and O6-alkylguanine in DNA were compared immediately after the treatment and after a 20-hr incubation. Cells were able to excise 3-alkyladenine and 7-alkylguanine, but there was no loss of O6-alkylguanine, after correction for dilution, due to DNA synthesis during posttreatment incubation. The inability of Chinese hamster ovary cells fail to show growing point mutagenesis after treatment with N-ethyl-N-nitrosourea.

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Year:  1980        PMID： 7388815

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  16 in total

1.  Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells.

Authors:  H Sockett; S Romac; F Hutchinson
Journal:  Mol Gen Genet       Date:  1991-06

2.  Site-specific mutagenesis by O6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O6-alkylguanine-DNA alkyltransferase.

Authors:  K S Ellison; E Dogliotti; T D Connors; A K Basu; J M Essigmann
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

3.  The proline rich domain of p53 is dispensable for MGMT-dependent DNA repair and cell survival following alkylation damage.

Authors:  Katherine Baran; Mao Yang; Christopher P Dillon; Leona L Samson; Douglas R Green
Journal:  Cell Death Differ       Date:  2017-07-28       Impact factor: 15.828

4.  Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells.

Authors:  B Kaina; A A Van Zeeland; C Backendorf; H W Thielmann; P Van de Putte
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272

5.  Cell cycle-specific mutagenesis at the hypoxanthine phosphoribosyltransferase locus in adult rat liver epithelial cells.

Authors:  C Tong; M Fazio; G M Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

6.  Adaptive increase of O6-methylguanine-acceptor protein in HeLa cells following N-methyl-N'-nitro-N-nitrosoguanidine treatment.

Authors:  E A Waldstein; E H Cao; R B Setlow
Journal:  Nucleic Acids Res       Date:  1982-08-11       Impact factor: 16.971

Review 7.  Drug resistance and DNA repair.

Authors:  M Fox; J J Roberts
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

8.  Differences in temporal aspects of mutagenesis and cytotoxicity in Chinese hamster cells treated with methylating agents and thymidine.

Authors:  A R Peterson; H Peterson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

9.  Adaptive resynthesis of O6-methylguanine-accepting protein can explain the differences between mammalian cells proficient and deficient in methyl excision repair.

Authors:  E A Waldstein; E H Cao; R B Setlow
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

10.  Strand breaks arising from the repair of the 5-bromodeoxyuridine-substituted template and methyl methanesulphonate-induced lesions can explain the formation of sister chromatid exchanges.

Authors:  R Saffhill; C H Ockey
Journal:  Chromosoma       Date:  1985       Impact factor: 4.316
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