Literature DB >> 7388309

The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man.

S E Knight, R L McIsaac, C D Rennie.   

Abstract

Histamine has been investigated for its effect on gastric acid secretion and mucosal blood flow in man. Dose-response curves were constructed and analysed in the presence of H1- and H2-antagonists. Mepyramine had no effect on acid secretion or mucosal blood flow. Cimetidine reduced acid secretion but had no effect on blood flow. This suggests that the vasculature is less sensitive to cimetidine than the parietal cell.

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Year:  1980        PMID： 7388309     DOI： 10.1002/bjs.1800670412

Source DB:  PubMed          Journal:  Br J Surg        ISSN： 0007-1323            Impact factor:   6.939


  7 in total

1.  Somatostatin reduces gastric mucosal blood flow in normal subjects but not in patients with cirrhosis of the liver.

Authors:  A Sonnenberg; C West
Journal:  Gut       Date:  1983-02       Impact factor: 23.059

2.  Does gastric aminopyrine clearance reflect gastric mucosal blood flow or parietal cell function?

Authors:  S A Müller-Lissner; A Sonnenberg; A L Blum
Journal:  Gut       Date:  1981-12       Impact factor: 23.059

3.  Effect of nicotine on gastric mucosal blood flow and acid secretion.

Authors:  A Sonnenberg; N Hüsmert
Journal:  Gut       Date:  1982-06       Impact factor: 23.059

4.  Endoscopic measurement of gastric corpus mucosal blood flow in conscious dogs.

Authors:  F W Leung; J Washington; G L Kauffman; P H Guth
Journal:  Dig Dis Sci       Date:  1986-06       Impact factor: 3.199

5.  Effect of cimetidine on augmented gastric blood flow in duodenal ulcer patients.

Authors:  L Ivarsson; N Darle; O Lundgren
Journal:  Gut       Date:  1984-10       Impact factor: 23.059

6.  Gastric acid secretion induced by impromidine in the dog and man: analysis of dose-response relationships.

Authors:  R L McIsaac; B J Johnston; M C Flannery; L P Fielding
Journal:  Agents Actions       Date:  1982-04

7.  Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist.

Authors:  R L McIsaac; B J Johnston; L P Fielding
Journal:  Gut       Date:  1981-07       Impact factor: 23.059
  7 in total

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