Literature DB >> 6455334

Gastric mucosal blood flow and acid secretory changes in man with impromidine: a new specific histamine-H2-receptor agonist.

R L McIsaac, B J Johnston, L P Fielding.   

Abstract

The effect of impromidine, a new histamine-H2-receptor agonist, on gastric mucosal blood flow (neutral red clearance) and acid secretion was studied in nine volunteers. Impromidine stimulated a dose-dependent increase in neutral red clearance and acid secretion. Simultaneous cimetidine in three doses caused a parallel shift to the right for both acid output and clearance with unchanged maxima compatible with simple surmountable antagonism. There were small cardiovascular changes: an increased heart rate with a decreased diastolic pressure during infusion of impromidine. These changes were antagonised by cimetidine.

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Year:  1981        PMID： 6455334      PMCID： PMC1419320          DOI： 10.1136/gut.22.7.529

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  8 in total

1.  Definition and antagonism of histamine H 2 -receptors.

Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

2.  Aminopyrine clearance in the damaged gastric mucosa: reconciliation of conflicting data.

Authors:  H W Davenport; D Munro
Journal:  Gastroenterology       Date:  1973-09       Impact factor: 22.682

3.  Vacuum aspiration of the uterus in therapeutic abortion.

Authors:  A E Buckle; M M Anderson; K C Loung
Journal:  Br Med J       Date:  1970-05-23

4.  Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors.

Authors:  G J Durant; W A Duncan; C R Ganellin; M E Parsons; R C Blakemore; A C Rasmussen
Journal:  Nature       Date:  1978-11-23       Impact factor: 49.962

5.  Histamine H1- and H2-receptor vasodilation of canine intestinal circulation.

Authors:  W Pawlik; L L Tague; B L Tepperman; T A Miller; E D Jacobson
Journal:  Am J Physiol       Date:  1977-09

6.  Gastric secretion in relation to mucosal blood flow studied by a clearance technic.

Authors:  E D Jacobson; R H Linford; M I Grossman
Journal:  J Clin Invest       Date:  1966-01       Impact factor: 14.808

7.  Gastric secretory studies in humans with impromidine (SK&F 92676)--a specific histamine H2 receptor agonist.

Authors:  R H Hunt; J G Mills; J Beresford; J A Billings; W L Burland; G J Milton-Thompson
Journal:  Gastroenterology       Date:  1980-03       Impact factor: 22.682

8.  The effect of histamine and histamine antagonists on gastric acid secretion and mucosal blood flow in man.

Authors:  S E Knight; R L McIsaac; C D Rennie
Journal:  Br J Surg       Date:  1980-04       Impact factor: 6.939
  8 in total
  2 in total

1.  Effect of cimetidine on the hepatic extraction of indocyanine green, the portal pressure and the systemic circulation in patients with cirrhosis of the liver.

Authors:  R Herz; M Rössle; T Bonzel; E Keller; W Gerok
Journal:  Klin Wochenschr       Date:  1984-08-16

2.  Gastric acid secretion induced by impromidine in the dog and man: analysis of dose-response relationships.

Authors:  R L McIsaac; B J Johnston; M C Flannery; L P Fielding
Journal:  Agents Actions       Date:  1982-04
  2 in total

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