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Literature DB >> 7387405

Gene constellation of live influenza A vaccines.

Abstract

The genotypic composition of several H3N2 vaccinal strains made from PR/8/34 and different wild isolates has been determined. The results suggested that specific gene constellations at the level of the 3 largest RNA fragments, coding the 3 "polymerase proteins" are responsible for their consistent attenuation.

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Year: 1980 PMID： 7387405 DOI： 10.1007/bf01318021

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

6 in total

1. RNAs of influenza virus recombinants derived from parents of known virulence for man.

Authors: G Florent; M Lobmann; A S Beare; N Zygraich
Journal: Arch Virol Date: 1977 Impact factor: 2.574

2. The genes of influenza virus.

Authors: P Palese
Journal: Cell Date: 1977-01 Impact factor: 41.582

3. Procedures for characterisation of the genetic material of candidate vaccine strains.

Authors: A J Hay; A R Bellamy; G Abraham; J J Skehel; C M Brand; R G Webster
Journal: Dev Biol Stand Date: 1977 Jun 1-3

4. Trials in man with live recombinants made from A/PR/8/34 (H0 N1) and wild H3 N2 influenza viruses.

Authors: A S Beare; G C Schild; J W Craig
Journal: Lancet Date: 1975-10-18 Impact factor: 79.321

5. Correlation of pathogenicity and gene constellation of influenza A viruses. III. Non-pathogenic recombinants derived from highly pathogenic parent strains.

Authors: R Rott; M Orlich; C Scholtissek
Journal: J Gen Virol Date: 1979-08 Impact factor: 3.891

6. Recombinant influenza-A viruses as live vaccines for man. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines.

Authors: A S Beare; T S Hall
Journal: Lancet Date: 1971-12-11 Impact factor: 79.321

6 in total

14 in total

1. The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/Pintail/79 reassortant viruses for monkeys.

Authors: M H Snyder; A J Buckler-White; W T London; E L Tierney; B R Murphy
Journal: J Virol Date: 1987-09 Impact factor: 5.103

2. Molecular characteristics and biological properties (genetic markers) of candidate strains for preparation of live influenza virus vaccines.

Authors: Y Z Ghendon
Journal: Bull World Health Organ Date: 1984 Impact factor: 9.408

3. Plaquing characteristics of influenza A virus recombinants of defined genetic composition. Brief report.

Authors: J S Oxford; K A Callow; T Corcoran; A S Beare
Journal: Arch Virol Date: 1982 Impact factor: 2.574

4. Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.

Authors: M L Clements; E K Subbarao; L F Fries; R A Karron; W T London; B R Murphy
Journal: J Clin Microbiol Date: 1992-03 Impact factor: 5.948

5. A determinant of polyomavirus virulence enhances virus growth in cells of renal origin.

Authors: J B Bolen; S E Fisher; K Chowdhury; T C Shan; J E Williams; C J Dawe; M A Israel
Journal: J Virol Date: 1985-01 Impact factor: 5.103

6. The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus.

Authors: Amorsolo L Suguitan; Michael P Marino; Purvi D Desai; Li-Mei Chen; Yumiko Matsuoka; Ruben O Donis; Hong Jin; David E Swayne; George Kemble; Kanta Subbarao
Journal: Virology Date: 2009-10-14 Impact factor: 3.616

10. Live influenza A/Victoria/75 (H3N2) virus vaccines: reactogenicity, immunogenicity, and protection against wild-type virus challenge.

Authors: T R Cate; R B Couch
Journal: Infect Immun Date: 1982-10 Impact factor: 3.441