Literature DB >> 19833372

The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus.

Amorsolo L Suguitan1, Michael P Marino, Purvi D Desai, Li-Mei Chen, Yumiko Matsuoka, Ruben O Donis, Hong Jin, David E Swayne, George Kemble, Kanta Subbarao.   

Abstract

A recombinant live attenuated influenza virus DeltaH5N1 vaccine with a modified hemagglutinin (HA) and intact neuraminidase genes from A/Vietnam/1203/04 (H5N1) and six remaining genome segments from A/Ann Arbor/6/60 (H2N2) cold-adapted (AA ca) virus was previously shown to be attenuated in chickens, mice and ferrets. Evaluation of the recombinant H5N1 viruses in mice indicated that three independent factors contributed to the attenuation of the DeltaH5N1 vaccine: the attenuating mutations specified by the AA ca loci had the greatest influence, followed by the deletion of the H5 HA multi-basic cleavage site (MBS), and the constellation effects of the AA genes acting in concert with the H5N1 glycoproteins. Restoring the MBS in the H5 HA of the vaccine virus improved its immunogenicity and efficacy, likely as a consequence of increased virus replication, indicating that removal of the MBS had a deleterious effect on the immunogenicity and efficacy of the DeltaH5N1 vaccine in mice.

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Year:  2009        PMID： 19833372      PMCID： PMC2787913          DOI： 10.1016/j.virol.2009.09.017

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  33 in total

1.  Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide.

Authors:  S G Lazarowitz; P W Choppin
Journal:  Virology       Date:  1975-12       Impact factor: 3.616

2.  Imparting temperature sensitivity and attenuation in ferrets to A/Puerto Rico/8/34 influenza virus by transferring the genetic signature for temperature sensitivity from cold-adapted A/Ann Arbor/6/60.

Authors:  Hong Jin; Helen Zhou; Bin Lu; George Kemble
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

3.  Validation of egg yolk antibody testing as a method to determine influenza status in white leghorn hens.

Authors:  J R Beck; D E Swayne; S Davison; S Casavant; C Gutierrez
Journal:  Avian Dis       Date:  2003       Impact factor: 1.577

4.  Molecular determinants within the surface proteins involved in the pathogenicity of H5N1 influenza viruses in chickens.

Authors:  Diane J Hulse; Robert G Webster; Rupert J Russell; Daniel R Perez
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

5.  Correlation of pathogenicity and gene constellation of influenza A viruses. II. Highly neurovirulent recombinants derived from non-neurovirulent or weakly neurovirulent parent virus strains.

Authors:  C Scholtissek; A Vallbracht; B Flehmig; R Rott
Journal:  Virology       Date:  1979-06       Impact factor: 3.616

6.  The structure of the hemagglutinin, a determinant for the pathogenicity of influenza viruses.

Authors:  F X Bosch; M Orlich; H D Klenk; R Rott
Journal:  Virology       Date:  1979-05       Impact factor: 3.616

7.  Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.

Authors:  M Hatta; P Gao; P Halfmann; Y Kawaoka
Journal:  Science       Date:  2001-09-07       Impact factor: 47.728

8.  Acquisition of a polybasic hemagglutinin cleavage site by a low-pathogenic avian influenza virus is not sufficient for immediate transformation into a highly pathogenic strain.

Authors:  Olga Stech; Jutta Veits; Siegfried Weber; Daniela Deckers; Diana Schröer; Thomas W Vahlenkamp; Angele Breithaupt; Jens Teifke; Thomas C Mettenleiter; Jürgen Stech
Journal:  J Virol       Date:  2009-03-18       Impact factor: 5.103

9.  Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate.

Authors:  H Chen; Y Matsuoka; David Swayne; Q Chen; N J Cox; B R Murphy; K Subbarao
Journal:  Vaccine       Date:  2003-10-01       Impact factor: 3.641

10.  Recombinant paramyxovirus type 1-avian influenza-H7 virus as a vaccine for protection of chickens against influenza and Newcastle disease.

Authors:  D E Swayne; D L Suarez; S Schultz-Cherry; T M Tumpey; D J King; T Nakaya; P Palese; A Garcia-Sastre
Journal:  Avian Dis       Date:  2003       Impact factor: 1.577
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  16 in total

1.  Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets.

Authors:  Weijia Wang; Bin Lu; Helen Zhou; Amorsolo L Suguitan; Xing Cheng; Kanta Subbarao; George Kemble; Hong Jin
Journal:  J Virol       Date:  2010-04-28       Impact factor: 5.103

Review 2.  H5N1 vaccines in humans.

Authors:  Mariana Baz; Catherine J Luke; Xing Cheng; Hong Jin; Kanta Subbarao
Journal:  Virus Res       Date:  2013-05-28       Impact factor: 3.303

3.  The matrix gene segment destabilizes the acid and thermal stability of the hemagglutinin of pandemic live attenuated influenza virus vaccines.

Authors:  Christopher D O'Donnell; Leatrice Vogel; Yumiko Matsuoka; Hong Jin; Kanta Subbarao
Journal:  J Virol       Date:  2014-08-13       Impact factor: 5.103

4.  Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus.

Authors:  Seema S Lakdawala; Elaine W Lamirande; Amorsolo L Suguitan; Weijia Wang; Celia P Santos; Leatrice Vogel; Yumiko Matsuoka; William G Lindsley; Hong Jin; Kanta Subbarao
Journal:  PLoS Pathog       Date:  2011-12-29       Impact factor: 6.823

5.  The multibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammals.

Authors:  Amorsolo L Suguitan; Yumiko Matsuoka; Yuk-Fai Lau; Celia P Santos; Leatrice Vogel; Lily I Cheng; Marlene Orandle; Kanta Subbarao
Journal:  J Virol       Date:  2011-12-28       Impact factor: 5.103

6.  A live attenuated H7N7 candidate vaccine virus induces neutralizing antibody that confers protection from challenge in mice, ferrets, and monkeys.

Authors:  Ji-Young Min; Leatrice Vogel; Yumiko Matsuoka; Bin Lu; David Swayne; Hong Jin; George Kemble; Kanta Subbarao
Journal:  J Virol       Date:  2010-09-01       Impact factor: 5.103

Review 7.  Clinical vaccine development for H5N1 influenza.

Authors:  Christopher H Clegg; Joseph A Rininger; Susan L Baldwin
Journal:  Expert Rev Vaccines       Date:  2013-07       Impact factor: 5.217

8.  Intranasal delivery of an IgA monoclonal antibody effective against sublethal H5N1 influenza virus infection in mice.

Authors:  Jianqiang Ye; Hongxia Shao; Danielle Hickman; Matthew Angel; Kemin Xu; Yibin Cai; Haichen Song; Ron A M Fouchier; Aijian Qin; Daniel R Perez
Journal:  Clin Vaccine Immunol       Date:  2010-07-28

9.  A pandemic influenza H1N1 live vaccine based on modified vaccinia Ankara is highly immunogenic and protects mice in active and passive immunizations.

Authors:  Annett Hessel; Michael Schwendinger; Daniela Fritz; Sogue Coulibaly; Georg W Holzer; Nicolas Sabarth; Otfried Kistner; Walter Wodal; Astrid Kerschbaum; Helga Savidis-Dacho; Brian A Crowe; Thomas R Kreil; P Noel Barrett; Falko G Falkner
Journal:  PLoS One       Date:  2010-08-16       Impact factor: 3.240

10.  Neutralizing epitopes of the SARS-CoV S-protein cluster independent of repertoire, antigen structure or mAb technology.

Authors:  Jody D Berry; Kevin Hay; James M Rini; Meng Yu; Linfa Wang; Francis A Plummer; Cindi R Corbett; Anton Andonov
Journal:  MAbs       Date:  2010-01-27       Impact factor: 5.857
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