Literature DB >> 7380481

Inhibition or killing of an intracellular pathogen by activated macrophages is abrogated by TLCK or aminophylline.

R McLeod, J S Remington.   

Abstract

Agents that are known to inhibit certain metabolic pathways or cell functions were evaluated to determine their effects on the capacity of activated macrophages to inhibit or kill obligate intracellular pathogens. Tosyllysine chloromethyl ketone (TLCK) and aminophylline abrogate inhibition or killing of Toxoplasma gondii by activated macrophages.

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Year:  1980        PMID： 7380481      PMCID： PMC1458029     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  17 in total

1.  Editorial: How lymphocytes kill tumor cells.

Authors:  A C Allison; J Ferluga
Journal:  N Engl J Med       Date:  1976-07-15       Impact factor: 91.245

2.  Lymphocyte-macrophage interaction during control of intracellular parasitism.

Authors:  T C Jones; H Masur; L Len; T L Fu
Journal:  Am J Trop Med Hyg       Date:  1977-11       Impact factor: 2.345

3.  Oxygen-dependent microbial killing by phagocytes (first of two parts).

Authors:  B M Babior
Journal:  N Engl J Med       Date:  1978-03-23       Impact factor: 91.245

4.  Macrophage tumor killing: influence of the local environment.

Authors:  J B Hibbs; R R Taintor; H A Chapman; J B Weinberg
Journal:  Science       Date:  1977-07-15       Impact factor: 47.728

5.  In vitro studies of immunologically induced secretion of mediators from cells and related phenomena.

Authors:  E L Becker; P M Henson
Journal:  Adv Immunol       Date:  1973       Impact factor: 3.543

Review 6.  Selective chemical modification of proteins.

Authors:  E Shaw
Journal:  Physiol Rev       Date:  1970-04       Impact factor: 37.312

7.  Studies on the specificity of killing of intracellular pathogens by macrophages.

Authors:  R McLeod; J S Remington
Journal:  Cell Immunol       Date:  1977-11       Impact factor: 4.868

8.  Antibody-dependent cell-mediated cytotoxicity in humans. III. Effect of protease inhibitors and substrates.

Authors:  G Trinchieri; M De Marchi
Journal:  J Immunol       Date:  1976-04       Impact factor: 5.422

9.  Microbicidal mechanisms of human granulocytes: synergistic effects of granulocyte elastase and myeloperoxidase or chymotrypsin-like cationic protein.

Authors:  H Odeberg; I Olsson
Journal:  Infect Immun       Date:  1976-12       Impact factor: 3.441

10.  Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors.

Authors:  K F AUSTEN; W E BROCKLEHURST
Journal:  J Exp Med       Date:  1961-03-01       Impact factor: 14.307
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  1 in total

1.  Oxygen-independent killing by alveolar macrophages.

Authors:  J R Catterall; S D Sharma; J S Remington
Journal:  J Exp Med       Date:  1986-05-01       Impact factor: 14.307
  1 in total

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