Literature DB >> 327547

Macrophage tumor killing: influence of the local environment.

J B Hibbs, R R Taintor, H A Chapman, J B Weinberg.   

Abstract

Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.

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Year:  1977        PMID： 327547     DOI： 10.1126/science.327547

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  60 in total

Review 1.  Many cytokines are very useful therapeutic targets in disease.

Authors:  Marc Feldmann
Journal:  J Clin Invest       Date:  2008-11       Impact factor: 14.808

2.  Effects of inhibitors of tumoricidal activity upon schistosomulum killing by activated macrophages.

Authors:  S L James; J A Glaven
Journal:  Infect Immun       Date:  1987-12       Impact factor: 3.441

3.  Peritoneal macrophage activation indicated by enhanced chemiluminescence.

Authors:  C J Schleupner; L A Glasgow
Journal:  Infect Immun       Date:  1978-09       Impact factor: 3.441

4.  Nitrogen monoxide (NO) storage and transport by dinitrosyl-dithiol-iron complexes: long-lived NO that is trafficked by interacting proteins.

Authors:  Yohan Suryo Rahmanto; Danuta S Kalinowski; Darius J R Lane; Hiu Chuen Lok; Vera Richardson; Des R Richardson
Journal:  J Biol Chem       Date:  2012-01-19       Impact factor: 5.157

5.  Identification and characterization of a monoclonal antibody to an antigen expressed on activated macrophages.

Authors:  T P Koestler; D Rieman; K Muirhead; R G Greig; G Poste
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

6.  Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

Authors:  S Beissert; M Bergholz; I Waase; G Lepsien; A Schauer; K Pfizenmaier; M Krönke
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

7.  Effects of BCG infection on the susceptibility of mouse macrophages to endotoxin.

Authors:  D L Peavy; R E Baughn; D M Musher; D M Musher
Journal:  Infect Immun       Date:  1979-04       Impact factor: 3.441

8.  A membrane vesicle/ribosome preparation from Serratia marcescens elicits peritoneal exudate cells expressing both tumoricidal and bactericidal activity.

Authors:  C McCall; L Weimer; S Baldwin; D W Riches; B Canono; P A Campbell
Journal:  Inflammation       Date:  1992-08       Impact factor: 4.092

9.  Cytotoxic cells induced after Chlamydia psittaci infection in mice.

Authors:  J K Lammert
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441

10.  Macrophage polykaryon formation in vitro by peritoneal cells from mice given injections of sodium periodate.

Authors:  J B Weinberg
Journal:  Am J Pathol       Date:  1983-02       Impact factor: 4.307
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