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Literature DB >> 7380477

Inhibition of neutrophil migration by aggregated immunoglobulin attached to micropore membranes.

Abstract

The effect of substrate-bound immunoglobulin on neutrophil migration was examined. Immunoglobulin aggregates bound to micropore membranes inhibited the neutrophil response to a chemotactic stimulus. This inhibition was reversed by the presence of aggregates in suspension suggesting competition between substrate-bound and free aggregates for neutrophil surface binding sites. The immobilization of neutrophils by substrate-bound aggregated immunoglobulin suggests a mechanism for the accumulation of neutrophils at sites of immune complex deposition and tissue-bound antibodies in vivo.

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Substances：

Year: 1980 PMID： 7380477 PMCID： PMC1458017

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

14 in total

1. Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex disease.

Authors: R B Johnston; J E Lehmeyer
Journal: J Clin Invest Date: 1976-04 Impact factor: 14.808

2. A proposal for the definition of terms related to locomotion of leucocytes and other cells.

Authors: H U Keller; P C Wilkinson; M Abercrombie; E L Becker; J G Hirsch; M E Miller; W Scottramsey; S H Zigmond
Journal: Clin Exp Immunol Date: 1977-03 Impact factor: 4.330

3. Analysis of individual leucocyte behavior during chemotaxis..

Authors: W S Ramsey
Journal: Exp Cell Res Date: 1972-01 Impact factor: 3.905

4. Cell-substrate adhesivity. A determinant of cell motility.

Authors: M H Gail; C W Boone
Journal: Exp Cell Res Date: 1972-01 Impact factor: 3.905

5. Interaction of cells with immune complexes: adherence, release of constituents, and tissue injury.

Authors: P M Henson
Journal: J Exp Med Date: 1971-09-01 Impact factor: 14.307

6. The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

Authors: P M Henson
Journal: J Immunol Date: 1971-12 Impact factor: 5.422

7. Essential role of surface-bound chemoattractant in leukocyte migration.

Authors: M P Dierich; D Wilhelmi; G Till
Journal: Nature Date: 1977-11-24 Impact factor: 49.962

8. The release of granule enzymes from human neutrophils stimulated by aggregated immunoglobulins of different classes and subclasses.

Authors: P M Henson; H B Johnson; H L Spiegelberg
Journal: J Immunol Date: 1972-12 Impact factor: 5.422

9. Haptotaxis and the mechanism of cell motility.

Authors: S B Carter
Journal: Nature Date: 1967-01-21 Impact factor: 49.962

10. Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.

Authors: S H Zigmond; J G Hirsch
Journal: J Exp Med Date: 1973-02-01 Impact factor: 14.307

6 in total

6. Inflammatory synovial tissue mononuclear cells release leucocyte migration inhibition factor in antigen- and mitogen-free cultures.

Authors: T Egeland; O J Mellbye; J A Pahle
Journal: Ann Rheum Dis Date: 1981-08 Impact factor: 19.103