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Literature DB >> 6181922

The effect of salicylate on human leucocyte migration.

Abstract

The effect of sodium salicylate, at concentrations obtained in vivo, on the random migration and chemotactic response of neutrophils and monocytes was examined. Incubation of cells in vitro increased neutrophil migration but decreased monocyte migration. However, both neutrophil and monocyte migration were significantly increased when obtained from normal individuals after ingestion of sodium salicylate. Salicylate also partly reversed the inhibition of neutrophil migration produced by aggregated immunoglobulin bound to the filter substrate. These effects of salicylate on leucocyte function may contribute to the anti-inflammatory activity of the drug.

Entities: Chemical Species

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Year: 1982 PMID： 6181922 PMCID： PMC1536655

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

11 in total

1. Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.

Authors: R R MacGregor; P J Spagnuolo; A L Lentnek
Journal: N Engl J Med Date: 1974-09-26 Impact factor: 91.245

2. The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

Authors: P M Henson
Journal: J Immunol Date: 1971-12 Impact factor: 5.422

2. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo.

Authors: A Kharazmi; K Winther
Journal: Inflammopharmacology Date: 1999 Impact factor: 4.473

3. The anti-inflammatory properties of rose-hip.

Authors: K Winther; E Rein; A Kharazmi
Journal: Inflammopharmacology Date: 1999 Impact factor: 4.473

3 in total

The effect of salicylate on human leucocyte migration.

1. Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.

2. The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

3. A histopathological and pharmacological analysis of the mode of action of nonsteroidal anti-inflammatory drugs.

4. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

5. Inhibiting effect of non-steroidal anti-inflammatory drugs on the chemotaxis of human leukocytes in vitro.

6. Inhibition of neutrophil migration by aggregated immunoglobulin attached to micropore membranes.

7. Inhibition of neutrophil migration by sera from patients with rheumatoid arthritis.

8. Effect of one gold salt, of betamethasone, and of aspirin on the chemotaxis of human neutrophils measured in vitro.

9. Modulating influence of chemotactic factor-induced cell adhesiveness on granulocyte function.

10. Monocyte chemotaxis under agarose: defects in atopic disease, aspirin therapy, and mucocutaneous candidiasis.

1. Tolfenamic acid inhibits leukotriene B4-induced chemotaxis of polymorphonuclear leukocytes in vitro.

2. Rose hip inhibits chemotaxis and chemiluminescence of human peripheral blood neutrophils in vitro and reduces certain inflammatory parameters in vivo.

3. The anti-inflammatory properties of rose-hip.