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Literature DB >> 7380468

Immune mechanisms against canine distemper. III. Role of complement lysis in the immunity and persistent infection of canine distemper virus.

Abstract

Antibody-mediated complement lysis of Vero cells and canine macrophages infected with canine distemper virus (CDV) was demonstratee in an in vitro 51Cr release assay. This cytolytic activity was found to be highly efficient and was optimal under conditions which favoured the capping of redistribution of surface viral antigens. A prozone was observed in the presence of high antibody concentration and could not be eliminated by repeated washings. By tagging antibody-coated target cells with 125I-labelled staphylococcus protein A, it was found that the extent of protein A binding was parallel to the degree of cytotoxicity suggesting that the mechanism of this prozone effect was similar to that of a precipitation test.

Entities: Chemical Disease Species

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Year: 1980 PMID： 7380468 PMCID： PMC1457963

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

15 in total

1. Solid-phase radioimmunoassay for detecting bovine (neonatal calf diarrhea) rotavirus antibody.

Authors: L A Babiuk; S D Acres; B T Rouse
Journal: J Clin Microbiol Date: 1977-07 Impact factor: 5.948

2. [Cytotoxic reactions in cells infected with Sendai virus].

Authors: F Kieling; G Bandlow; R Thomssen
Journal: Arch Gesamte Virusforsch Date: 1972

3. Measles and multiple sclerosis.

Authors: E Norrby; B Vandvik
Journal: Proc R Soc Med Date: 1974-11

4. Latent measles virus infection of the hamster central nervous system.

Authors: D J Wear; F Rapp
Journal: J Immunol Date: 1971-12 Impact factor: 5.422

5. Immunologic injury in measles virus infection. IV. Antigens modulation and abrogation oflymphocyte lysis of virus-infected cells.

Authors: M B Oldstone; A Tishon
Journal: Clin Immunol Immunopathol Date: 1978-01

6. Characterization of measles virus-specific cytotoxic antibodies by use of a chronically infected cell line.

Authors: A C Ehrnst
Journal: J Immunol Date: 1975-03 Impact factor: 5.422

7. Protein A reactivity of various mammalian immunoglobulins.

Authors: J Goudswaard; J A van der Donk; A Noordzij; R H van Dam; J P Vaerman
Journal: Scand J Immunol Date: 1978 Impact factor: 3.487

8. Studies on the persistent infection with measles virus in HeLa cells. 3. Immunolysis of cells in carrier state by anti-measles sera.

Authors: T Minagawa; M Yamada
Journal: Jpn J Microbiol Date: 1971-07

4. Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs. Sequential immunologic and morphologic findings.

Authors: R J Higgins; S G Krakowka; A E Metzler; A Koestner
Journal: Acta Neuropathol Date: 1982 Impact factor: 17.088

4 in total

Immune mechanisms against canine distemper. III. Role of complement lysis in the immunity and persistent infection of canine distemper virus.

1. Solid-phase radioimmunoassay for detecting bovine (neonatal calf diarrhea) rotavirus antibody.

2. [Cytotoxic reactions in cells infected with Sendai virus].

3. Measles and multiple sclerosis.

4. Latent measles virus infection of the hamster central nervous system.

5. Immunologic injury in measles virus infection. IV. Antigens modulation and abrogation oflymphocyte lysis of virus-infected cells.

6. Characterization of measles virus-specific cytotoxic antibodies by use of a chronically infected cell line.

7. Protein A reactivity of various mammalian immunoglobulins.

8. Studies on the persistent infection with measles virus in HeLa cells. 3. Immunolysis of cells in carrier state by anti-measles sera.

9. Possible initiation of viral encephalomyelitis in dogs by migrating lymphocytes infected with distemper virus.

10. Immunologic injury in measles virus infection. II. Suppression of immune injury through antigenic modulation.

1. Canine distemper virus clearance in chronic inflammatory demyelination.

2. Immunopathogenic and neurological mechanisms of canine distemper virus.

3. Studies on the intrathecal humoral immune response in canine distemper encephalitis.

4. Primary demyelination in experimental canine distemper virus induced encephalomyelitis in gnotobiotic dogs. Sequential immunologic and morphologic findings.